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EC Number
Protein Variants
Commentary
Reference
3.6.4.6
A505L
lethal mutation
654648
3.6.4.6
E350Q
lethal mutation
654648
3.6.4.6
G89D
higher intrinsic ATPase activity than wild-type, no stimulation by Sec17
654648
3.6.4.6
E233Q
no ATP hydrolysis, enhanced binding to Vps20p and Vta1p in vitro
656345
3.6.4.6
K179A
no ATP binding, enhanced binding to Vps20p and Vta1p in vitro
656345
3.6.4.6
E235Q
no ATPase activity, mutation leads to perturbation of various membrane transports via endosomes
656346
3.6.4.6
E329Q
no ATPase activity
656661
3.6.4.6
K266A
no nucleotide binding
656661
3.6.4.6
K549A
decrease in NSF vesicular transport activity
656661
3.6.4.6
more
NSF DELTA-N mutant fails to bind to SNAP-SNARE complex
656661
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