EC Number   |
Protein Variants |
Reference |
|---|
    3.5.4.1 | A23L/D92E/V108I/I140L |
construction of superimposed mutants by combining randomly generated single nucleotide mutants with the triple mutant, the superimposed mutant does not show enhanced activity with 5-fluorouracil and negates the effect introduced by the triple substitutions |
688408 |
| 3.5.4.1 | A23L/I140L |
site-directed mutagenesis, the mutant display elevated unfolding temperatures in denaturation experiments and increased half-lives of catalytic activity at elevated temperatures, the mutant cells show an about 30% reduced sensitivity to 5-fluorouracil compared to the wild-type cells |
688408 |
| 3.5.4.1 | A23L/M93L/V108I/I140L |
construction of superimposed mutants by combining randomly generated single nucleotide mutants with the triple mutant, the superimposed mutant does not show enhanced activity with 5-fluorouracil and negates the effect introduced by the triple substitutions |
688408 |
| 3.5.4.1 | A23L/V108I/I140L |
site-directed mutagenesis, display elevated unfolding temperatures in denaturation experiments and increased half-lives of catalytic activity at elevated temperatures, the mutant cells show an about 50% reduced sensitivity to 5-fluorouracil compared to the wild-type cells |
688408 |
| 3.5.4.1 | A23L/V108I/I140L/I98L |
construction of superimposed mutants by combining randomly generated single nucleotide mutants with the triple mutant, the superimposed mutant does not show enhanced activity with 5-fluorouracil and negates the effect introduced by the triple substitutions |
688408 |
| 3.5.4.1 | C320A |
mutant shows anti-HIV-1 activity comparable to wild-type |
720348 |
| 3.5.4.1 | C320D |
mutant shows anti-HIV-1 activity comparable to wild-type |
720348 |
| 3.5.4.1 | C320F |
mutant shows anti-HIV-1 activity comparable to wild-type |
720348 |
| 3.5.4.1 | C320K |
mutant shows anti-HIV-1 activity comparable to wild-type |
720348 |
| 3.5.4.1 | C320L |
mutant shows anti-HIV-1 activity comparable to wild-type |
720348 |
