EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.106 | H203A/D257A/S353A |
overexpression of catalytically inactive mutant hepsin abrogates its ability to induce tumor growth in a mouse model |
698324 |
| 3.4.21.106 | more |
biological functions and effects of hepsin are analysed in vitro and in vivo, using endometrial cancer cell lines Ishikawa, HEC-1A, stably transfected with human hepsin. A significant inhibitory effect on cell growth in a monolayer culture system and in anchorage-independent cell growth in soft agar in vitro is observed. In a xenograft model, growth inhibitory effects are shown observed when compared with the effects of mock-transfected cells used as a control. Hepsin shows potential inhibitory effects mediated by the induction of 14-3-3sigma expression which leads to both cell cycle arrest at the G2/M phase through cyclin B and cyclin A and the p53-dependent pathway activated by increasing the level of Bak and reducing the level of Bcl-2 and Bcl-xL |
698350 |
| 3.4.21.106 | more |
hepsin-deficient mice are viable and fertile, grow normally, have no detectable defects in liver histology and biochemistry. Blood clotting and tail bleeding times are also normal. Serum concentrations of bone-derived alkaline phosphatase are ca. 2fold higher in hepsin-deficient mice than in that of control mice |
686903 |
| 3.4.21.106 | more |
hepsin-overexpressing LNCaP prostate cancer cells also exhibit increased migration on Laminin-332 |
698824 |
| 3.4.21.106 | more |
overexpression of hepsin promotes ovarian tumor growth in a mouse model |
698324 |
| 3.4.21.106 | more |
Tmprss1-null mice exhibit profound hearing loss with elevated hearing thresholds compared with their heterozygous and wild-type littermates. Cochleae show abnormal tectorial membrane development, reduction in fiber compaction in the peripheral portion of the auditory nerve, and decreased expression of the myelin proteins myelin basic protein and myelin protein zero. Reduced level of the large conductance voltage- and Ca2+-activated K+ channel in the sensory hair cells. Significantly reduced free thyroxine levels |
684319 |
