EC Number   |
Protein Variants |
Reference |
|---|
    3.2.2.9 | A113P |
mutation of Vibrio cholera MTAN catalytic site residue to match those of Escherichia coli MTAN, about 4fold decrease in catalytic efficiency |
-, 749894 |
| 3.2.2.9 | A113P/V153I |
mutation of Vibrio cholera MTAN catalytic site residues to match those of Escherichia coli MTAN. In the Val153Ile mutant or double mutants, transition-state analogue binding at one site causes complete inhibition. Amino acid, Val153, alters the catalytic site cooperativity in MTAN |
-, 749894 |
| 3.2.2.9 | D168A |
completely inactive |
726889 |
| 3.2.2.9 | D168N |
completely inactive |
726889 |
| 3.2.2.9 | D197A |
enzyme is inactive with 5'-methylthioadenosine and S-adenosyl-L-homocysteine |
667622 |
| 3.2.2.9 | D197N |
enzyme is inactive with 5'-methylthioadenosine and S-adenosyl-L-homocysteine |
667622 |
| 3.2.2.9 | E12A |
enzyme is inactive with 5'-methylthioadenosine and S-adenosyl-L-homocysteine |
667622 |
| 3.2.2.9 | E12Q |
enzyme is inactive with 5'-methylthioadenosine and S-adenosyl-L-homocysteine |
667622 |
| 3.2.2.9 | E145Q |
completely inactive |
726889 |
| 3.2.2.9 | E173Q |
inactive |
727044 |
