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Information on EC 3.2.2.9 - adenosylhomocysteine nucleosidase

for references in articles please use BRENDA:EC3.2.2.9

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IUBMB Comments

This enzyme, found in bacteria and plants, acts on three different substrates. It is involved in the S-adenosyl-L-methionine (SAM, AdoMet) cycle, which recycles S-adenosyl-L-homocysteine back to SAM, and in salvage pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are produced from SAM during the action of many enzymes. cf. the plant enzyme EC 3.2.2.16, methylthioadenosine nucleosidase.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
nucleosidase, pfs-2, mta/adohcy nucleosidase, rv0091, s-adenosylhomocysteine nucleosidase, 5'-methylthioadenosine/s-adenosylhomocysteine, mtan-1, 5'-methylthioadenosine nucleosidases, adenosylhomocysteine nucleosidase, adohcy/mesado nucleosidase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine
show the reaction diagram
(2)
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S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
show the reaction diagram
S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine
show the reaction diagram
(3)
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PATHWAY SOURCE
PATHWAYS
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