EC Number   |
Protein Variants |
Reference |
|---|
    3.1.3.5 | 42DELTAN |
inactive mutant enzyme |
652165 |
| 3.1.3.5 | D351E |
strong decrease in nucleotidase activity, strong reduction in affinity towards Mg2+ |
664836 |
| 3.1.3.5 | D356E |
strong decrease in nucleotidase activity, strong reduction in affinity towards Mg2+ |
664836 |
| 3.1.3.5 | D356N |
strong increase in Km-value for inosine |
664836 |
| 3.1.3.5 | D396A |
site-directed mutagenesis, the mutant is only activable by 2,3-bisphosphoglycerate |
714967 |
| 3.1.3.5 | D41N |
specific activity of the mutant enzyme is 9.1% of the wild-type enzyme, activation by Co2+ is less than 2fold the level of activation of the wild-type enzyme |
649752 |
| 3.1.3.5 | D51N |
complete loss of activity |
730211 |
| 3.1.3.5 | D52A |
inactive mutant enzyme |
652165 |
| 3.1.3.5 | D52E |
inactive mutant enzyme |
652165 |
| 3.1.3.5 | D52N |
site-directed mutagenesis, catalytically inactive active site residue |
715932 |
