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EC Number
Protein Variants
Commentary
Reference
3.1.3.106
D58E
inactive
-
,
754084
3.1.3.106
D58N
inactive
-
,
754084
3.1.3.106
D60E
33.5% of wild-type activity
-
,
754084
3.1.3.106
D60N
inactive
-
,
754084
3.1.3.106
D9A
mutant is inactive towards lysophosphatidic acids
730152
3.1.3.106
H52A
mutation in putative active site, loss of activity
754054
3.1.3.106
L289W
about 50% of wild-type activity with substrate myristoyl-sn-glycerol 3-phosphate
755288
3.1.3.106
more
a mutant with deletion of the putative signal peptide has no catalytic activity
754054
3.1.3.106
R217K
adenoviral construction of an inactive isozyme LPP-1 mutant
663947
3.1.3.106
R217K
adenoviral construction of an isozyme LPP-1 mouse mutant showing partially attenuated LPA-induced interleukin-8 secretion without alteration of LPA-induced changes in intracellular Ca2+ concentration
663947
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