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Literature summary for 3.1.3.106 extracted from

  • Oguro, A.; Imaoka, S.
    Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase (2012), J. Lipid Res., 53, 505-512.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.106

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 about 60% stimulation, optimum activity at 0.02% Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
D9A mutant is inactive towards lysophosphatidic acids Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-palmitoyl-2-lyso-sn-glycerol 3-phosphate 40 microM, about 50% inhibition Homo sapiens
lauric acid 40 microM, about 60% inhibition Homo sapiens
lysophosphatidylcholine
-
 Homo sapiens
additional information not inhibitory: 1-palmitoyl-sn-glycerol, 1-hexadecanol Homo sapiens
palmitic acid 40 microM, about 80% inhibition Homo sapiens
stearic acid about 20% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 1-palmitoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens
0.0059
-
 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens
0.0062
-
 1-oleoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens
0.0064
-
 1-stearoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ in absence of Mg2+ activity towards 1-stearoyl-2-lyso-sn-glycerol 3-phosphate acid is significantly decreased Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-arachidonoyl-sn-glycerol + phosphate
-
 ?
1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-oleoyl-sn-glycerol + phosphate
-
 ?
1-palmitoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-palmitoyl-sn-glycerol + phosphate
-
 ?
1-stearoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-stearoyl-sn-glycerol + phosphate
-
 ?
additional information no substrates: dipalmitoyl phosphatidic acid, distearoyl phosphatidic acid Homo sapiens ?
-
 ?