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EC Number	Protein Variants	Commentary	Reference
2.6.1.7	E61G	40-60% of wild-type activity, Km for L-kynurenine and pyruvate is reduced, missense mutation found in spontaneously hypertensive rats	636639
2.6.1.7	E64G	the naturally occurring mutation in rat KAT I results in dramatically impaired kynurenic acid synthesis and in an associated spontaneously hypertensive phenotype	703351
2.6.1.7	more	use of an optimized codon sequence to overexpress histidine-tagged human KAT2 in an Escherichia coli expression system. The recombinant enzyme is catalytically active	739583
2.6.1.7	Y142F	active site mutation	722236

Results 1 - 4 of 4

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Release 2023.1 (January 2023)