EC Number   |
Protein Variants |
Reference  |
|---|
    2.5.1.22 | more |
enzyme null mutant, lack of spermine increases sensitivity of cells to anti-tumor agents |
489877 |
| 2.5.1.22 | more |
enzyme overexpression in transgenic mice under control of a composite CMV-IE enhancer-chicken beta-actin promotor causes no deleterious effects, the mice show normal growth, fertility, and behaviour, the content of S-adenosylmethionine in transgenic mice is important for viability, overview |
657842 |
| 2.5.1.22 | more |
the loss-of-function mutant of gene ACAULIS5 shows a severe defect in stem elongation, isolation of a T-DNA insertion mutant of gene SPMS, i.e. spms-1, showing decreased spermine levels but no obvious phenotypic alterations, an acl5-spms-1 double mutant contains no spermine but is fully viable as the wild-type and shows no phenotypic alterations under normal growth conditions, overview |
658727 |
| 2.5.1.22 | D201A |
40000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | D201N |
40000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | D276N |
250000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | E353Q |
1000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | more |
deletion of the N-terminal domain leads to a complete loss of spermine synthase activity |
687717 |
| 2.5.1.22 | more |
mutation p.G56S in the N-terminal region of spermine synthase greatly reduces spermine synthase activity and leads to severe epilepsy and cognitive impairment related to Snyder-Robinson X-linked recessive mental retardation syndrome |
688299 |
| 2.5.1.22 | more |
enzyme is able to functionally complement spermine deficiency in yeast |
689690 |
