EC Number   |
Protein Variants |
Reference |
|---|
    2.5.1.22 | DELTA1-43 |
0.0002% activity compared to the wild-type enzyme |
692270 |
| 2.5.1.22 | DELTA1-82 |
0.00023% activity compared to the wild-type enzyme |
692270 |
| 2.5.1.22 | DELTA1-19 |
0.003% activity compared to the wild-type enzyme |
692270 |
| 2.5.1.22 | DELTA1-129 |
0.02% activity compared to the wild-type enzyme |
692270 |
| 2.5.1.22 | E353Q |
1000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | D276N |
250000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | D201A |
40000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | D201N |
40000fold decrease in ratio kcat/Km value |
687717 |
| 2.5.1.22 | D276N |
alteration of this residue reduces the kcat/Km for spermidine by more than 200000fold |
692270 |
| 2.5.1.22 | more |
deletion of the N-terminal domain leads to a complete loss of spermine synthase activity |
687717 |
