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EC Number	Protein Variants	Commentary	Reference
1.5.1.34	A133S	-	485007
1.5.1.34	A133S	similar kcat for quinonoid dihydrobiopterin as wild-type	485005
1.5.1.34	A6V	no significant differences to wild-type	484965
1.5.1.34	D37I	lower kcat for quinonoid dihydrobiopterin than wild-type	485005
1.5.1.34	D37I	significant lower kcat	484965
1.5.1.34	G151S	mutation found in children suffering from phenylketonuria due to enzyme deficiency	485004
1.5.1.34	G19D	completely inactive	485002
1.5.1.34	G23D	mutation found in children suffering from phenylketonuria due to enzyme deficiency, inactive mutant enzyme	485004
1.5.1.34	K150I	lower kcat for quinonoid dihydrobiopterin than wild-type	485005
1.5.1.34	K150M	lower kcat for quinonoid dihydrobiopterin than wild-type	485005

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Release 2023.1 (January 2023)