Literature summary for 1.5.1.34 extracted from

Varughese, K.I.; Xuong, N.H.; Whiteley, J.M.
Structural and mechanistic implications of incorporating naturally occurring aberrant mutations of human dihydropteridine reductase into a rat model (1994), Int. J. Pept. Protein Res., 44, 278-287.

Search for more literature for 1.5.1.34

Cloned(Commentary)

Cloned (Comment)	Organism
expression of wild-type, G19D, W104G and T119insert mutant enzymes in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G19D	completely inactive	Homo sapiens
T119insert	reduced activity	Homo sapiens
W104G	similar activity as wild-type	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant wild-type, G19D, W104G and T119insert mutant enzymes	Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
56	-	T119 insert mutant enzyme	Homo sapiens
300	-	W104G mutant enzyme	Homo sapiens

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Release 2023.1 (January 2023)