EC Number   |
Protein Variants |
Reference  |
|---|
   1.14.11.27 | H212A |
mutation completely abolishes the enzymatic activity |
662947 |
| 1.14.11.27 | H305A |
mutation completely abolishes the enzymatic activity |
662947 |
| 1.14.11.27 | H305A |
more than 90% loss of activity |
688966 |
| 1.14.11.27 | more |
overexpression results in moderate decrease in dimethyl-histone 3 L-lysine 36 and a slight decrease in trimethyl-histone 3 L-lysine 36 along with unaltered methyl-histone 3 L-lysine 36 levels. Deletion of the N-terminal PHD domain leads to about 50% decrease in activity. Deletion of C-terminal 125, 193, or 244 amino acids results in more than 90% loss of activity |
688966 |
| 1.14.11.27 | T302A |
more than 90% loss of activity |
688966 |
| 1.14.11.27 | Y315A |
more than 90% loss of activity |
688966 |
| 1.14.11.27 | more |
expression of histone demthylase Ndy1 in mouse embryo fibroblast results in immortalization in absence of replicative senescence via a JmjC domain-dependent process that targets the Rb and p53 pathways. Knockdown of endogenous Ndy1 or expression of JmjC domain mutants of Ndy1 promote senescence, suggesting that Ndy1 is a physiological inhibitor of senescence in dividing cells and that inhibition of senescence depends on histone H3 demethylation |
689797 |
| 1.14.11.27 | more |
histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites |
698354 |
| 1.14.11.27 | H211A |
inactive mutant |
700374 |
| 1.14.11.27 | more |
Kdm2b/Jhmd1b is required for Hoxa9/Meis1-induced leukemic transformation in vitro |
724651 |
