Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.27 extracted from

  • Tsukada, Y.; Fang, J.; Erdjument-Bromage, H.; Warren, M.E.; Borchers, C.H.; Tempst, P.; Zhang, Y.
    Histone demethylation by a family of JmjC domain-containing proteins (2006), Nature, 439, 811-816.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required for optimal activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
H212A mutation completely abolishes the enzymatic activity Homo sapiens
H305A mutation completely abolishes the enzymatic activity Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme purified from baculovirus-infected Sf9 cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein 6-N,6-N-dimethyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Saccharomyces cerevisiae protein 6-N-methyl-L-lysine + succinate + formaldehyde + CO2
-
?
protein 6-N-methyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Saccharomyces cerevisiae protein L-lysine + succinate + formaldehyde + CO2
-
?
protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Homo sapiens protein N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
?
protein N6-methyl-L-lysine + 2-oxoglutarate + O2 specifically demethylates Lys36 of histone H3 Homo sapiens protein L-lysine + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
H3-K36 demethylase
-
Homo sapiens
H3-K36 demethylase
-
Saccharomyces cerevisiae
H3-K36-specific demethylase
-
Homo sapiens
histone-lysine(H3-K36) demethylase
-
Homo sapiens
JHDM1A
-
Homo sapiens
JmjC domain-containing histone demethylase 1
-
Homo sapiens
JmjC domain-containing histone demethylase 1A
-
Homo sapiens
scJHDM1
-
Saccharomyces cerevisiae