Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ascorbate | required for optimal activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H212A | mutation completely abolishes the enzymatic activity | Homo sapiens |
H305A | mutation completely abolishes the enzymatic activity | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme purified from baculovirus-infected Sf9 cells | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein 6-N,6-N-dimethyl-L-lysine + 2-oxoglutarate + O2 | specifically demethylates Lys36 of histone H3 | Saccharomyces cerevisiae | protein 6-N-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein 6-N-methyl-L-lysine + 2-oxoglutarate + O2 | specifically demethylates Lys36 of histone H3 | Saccharomyces cerevisiae | protein L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 | specifically demethylates Lys36 of histone H3 | Homo sapiens | protein N6-methyl-L-lysine + succinate + formaldehyde + CO2 | - |
? | |
protein N6-methyl-L-lysine + 2-oxoglutarate + O2 | specifically demethylates Lys36 of histone H3 | Homo sapiens | protein L-lysine + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H3-K36 demethylase | - |
Homo sapiens |
H3-K36 demethylase | - |
Saccharomyces cerevisiae |
H3-K36-specific demethylase | - |
Homo sapiens |
histone-lysine(H3-K36) demethylase | - |
Homo sapiens |
JHDM1A | - |
Homo sapiens |
JmjC domain-containing histone demethylase 1 | - |
Homo sapiens |
JmjC domain-containing histone demethylase 1A | - |
Homo sapiens |
scJHDM1 | - |
Saccharomyces cerevisiae |