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EC Number
Protein Variants
Commentary
Reference
2.3.1.286
H248Y
inactive
739412
2.3.1.286
H135A
the kcat/Km profile for the mutant exhibits no pH dependence over the range tested (pH 5.4-9.4), with kcat/Km values 2 orders of magnitude lower than wild type at high pH values
749880
2.3.1.286
E186A
inactive
750253
2.3.1.286
H135A
inactive
750253
2.3.1.286
Q115A
the mutant shows very weak deacetylation activity compared to the wild type enzyme
750253
2.3.1.286
S36A
inactive
750253
2.3.1.286
D101N
the mutation affects the deacetylation activity of the enzyme
-
,
750904
2.3.1.286
D118N
the mutant retains approximately 13% of the activity of the wild type protein
751549
2.3.1.286
I117A
inactive
751549
2.3.1.286
I117D
inactive
751549
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