EC Number   |
Protein Variants |
Reference |
|---|
   3.2.1.25 | R641H |
natural mutant identified in a patient with beta-mannosidisis. Patient is homozygous for the mutation, which leads to a residual activity of about 7% in the patient's leukocytes, 11% in lymphoblasts and 14% in plasma. Expression in transfected cells also results in 7% residual activity |
707885 |
| 3.2.1.25 | W198A |
low activity |
680752 |
| 3.2.1.25 | W198G |
crystallization data. Involved either in hydrogen bonding to the ligands or in the maintenance of the hydrophilic sheath around the ligand |
700352 |
| 3.2.1.25 | W200A |
low activity |
680752 |
| 3.2.1.25 | W345A |
crystallization data. Involved either in hydrogen bonding to the ligands or in the maintenance of the hydrophilic sheath around the ligand |
700352 |
| 3.2.1.25 | W395A |
low activity |
680752 |
| 3.2.1.25 | W645A |
crystallization data. Involved either in hydrogen bonding to the ligands or in the maintenance of the hydrophilic sheath around the ligand |
700352 |
| 3.2.1.25 | W645A |
low activity |
680752 |
| 3.2.1.25 | Y537A |
crystallization data. Involved either in hydrogen bonding to the ligands or in the maintenance of the hydrophilic sheath around the ligand |
700352 |
| 3.2.1.25 | Y537A |
low activity |
680752 |
