EC Number   |
Protein Variants |
Reference |
|---|
   2.7.7.7 | Y824A |
the mutation shows 25% increased polymerase activity compared to the wild type enzyme |
693076 |
| 2.7.7.7 | Y831A |
mutation of pol epsilon, slight sensitivity to hydroxyurea, semidominant mutator phenotype for frameshifts and base substitutions |
643664 |
| 2.7.7.7 | Y869A |
mutation of pol alpha, strain is viable, exhibits slow growth, sensitivity to hydroxyurea and spontaneous mutator phenotype for frameshifts and base substitutions |
643664 |
| 2.7.7.7 | Y955C |
naturally occuring mutation, involved in autosomal dominant progressive external ophthalmoplegia, the mutation is associated with motiif B in the active site, the mutant retains less than 1% of the wild-type polymerase activity and displays a severe decrease in processivity, the mutation increases nucleotide misinsertion replication errors 10-100 fold in the absence of exonucleolytic proofreading |
723108 |
