EC Number |
Protein Variants |
Reference |
---|
2.7.11.30 | K80A |
site-directed mutagenesis, the mutation affects binding of actividin |
665487 |
2.7.11.30 | L381P |
naturally occuring mutation in Japanese pulmonary arterial hypertension patients |
691833 |
2.7.11.30 | L40A |
site-directed mutagenesis, the mutation of a residue from the ALK4 extracellular domain affects the binding of activin and the substantial effects of the dominant negative truncated ALK4 mutant |
665487 |
2.7.11.30 | L75A |
site-directed mutagenesis, the mutation of a residue from the ALK4 extracellular domain affects the binding of activin and the substantial effects of the dominant negative truncated ALK4 mutant |
665487 |
2.7.11.30 | L85A |
site-directed mutagenesis, the mutation affects binding of actividin |
665487 |
2.7.11.30 | L90A |
site-directed mutagenesis, the mutation does not affect binding of actividin |
665487 |
2.7.11.30 | M53A |
site-directed mutagenesis, the mutation slightly affects binding of actividin |
665487 |
2.7.11.30 | more |
activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2, BMP2, BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures |
693381 |
2.7.11.30 | more |
ALK1 mutations cause hereditary hemorrhagic telangiectasia in association with pulmonary arterial hypertension, PAH, in patients, determination of polymorphisms in Japanese pulmonary arterial hypertension patients, phenotypes, overview |
691833 |
2.7.11.30 | more |
conferring of responsiveness to GDF-9-mediated stimulation of ALK5 and Smad3 phosphorylation in normally unresponsive COS-7 cells by overexpression of the three proteins, no responsiveness by co-expression with BMPRII receptor, expression of GDF-9 in a CAGA-luciferase reporter construct in P19 cells reveals that GDF-9 binds to BMP-activated type II receptors but its downstream actions are mediated by the type I receptor ALK5, overview, expression of ALK5 siRNA inhibits GDF-9-induced stimulation in granulosa cells |
666359 |