EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   3.4.24.86 | Neoplasms |
12065742 |
(E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-2'-(methanesulfonyl)-4-methylvalerohydrazide (Ro 32-7315), a selective and orally active inhibitor of tumor necrosis factor-alpha convertase. |
therapeutic application
unassigned |
2
0 |
| 3.4.24.86 | Neoplasms |
16298020 |
15,16-dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide. |
ongoing research
unassigned |
2
0 |
| 3.4.24.86 | Neoplasms |
9428736 |
2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode. |
ongoing research
unassigned |
1
0 |
| 3.4.24.86 | Neoplasms |
18284555 |
3D-quantitative structure-activity relationship studies on benzothiadiazepine hydroxamates as inhibitors of tumor necrosis factor-alpha converting enzyme. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
3
3
4
0 |
| 3.4.24.86 | Neoplasms |
16737974 |
5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. |
causal interaction
ongoing research
unassigned |
1
4
0 |
| 3.4.24.86 | Hypertension |
26254330 |
?-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
1
0 |
| 3.4.24.86 | Neoplasms |
15066987 |
A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin. |
diagnostic usage
unassigned |
3
0 |
| 3.4.24.86 | Neoplasms |
32822911 |
A combinational approach to restore cytokine balance and to inhibit virus growth may promote patient recovery in severe COVID-19 cases. |
causal interaction
unassigned |
1
0 |
| 3.4.24.86 | Neoplasms |
15801829 |
A comparison of the binding sites of matrix metalloproteinases and tumor necrosis factor-alpha converting enzyme: implications for selectivity. |
therapeutic application
unassigned |
2
0 |
| 3.4.24.86 | Neoplasms |
11878807 |
A continuous fluorimetric assay for tumor necrosis factor-alpha converting enzyme. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
1
3
2
0 |
