EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.24.86 | Neoplasms |
8753775 |
Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP. |
ongoing research
therapeutic application
unassigned |
3
1
0 |
| 3.4.24.86 | Neoplasms |
9428736 |
2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode. |
ongoing research
unassigned |
1
0 |
| 3.4.24.86 | Neoplasms |
9520379 |
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. |
ongoing research
unassigned |
3
0 |
| 3.4.24.86 | Neoplasms |
9521103 |
Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors. |
therapeutic application
unassigned |
4
0 |
| 3.4.24.86 | Osteoarthritis |
9574564 |
TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. |
unassigned |
0 |
| 3.4.24.86 | Neoplasms |
9598327 |
Genetic mapping of mouse tumor necrosis factor-alpha converting enzyme (TACE) to chromosome 12. |
unassigned |
0 |
| 3.4.24.86 | Neoplasms |
9733803 |
Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing. |
unassigned |
0 |
| 3.4.24.86 | Neoplasms |
9774383 |
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. |
unassigned |
0 |
| 3.4.24.86 | Neoplasms |
9812885 |
An essential role for ectodomain shedding in mammalian development. |
causal interaction
unassigned |
3
0 |
| 3.4.24.86 | Neoplasms |
10093737 |
Characterization of the tumour necrosis factor alpha-converting enzyme, TACE/ADAM17. |
diagnostic usage
ongoing research
unassigned |
1
3
0 |
