EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.23.B24 | Alzheimer Disease |
15385547 |
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. |
causal interaction
unassigned |
3
0 |
| 3.4.23.B24 | Alzheimer Disease |
16697367 |
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals. |
causal interaction
unassigned |
4
0 |
| 3.4.23.B24 | Breast Neoplasms |
32493324 |
Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
3
2
0 |
| 3.4.23.B24 | Carcinoma, Hepatocellular |
19337374 |
A small molecule inhibitor of signal Peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
1
4
4 |
| 3.4.23.B24 | Classical Swine Fever |
16439547 |
Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
1
1
2
0 |
| 3.4.23.B24 | Dehydration |
33627966 |
Physiological and molecular responses for long term salinity stress in common fig (Ficus carica L.). |
ongoing research
unassigned |
2
0 |
| 3.4.23.B24 | Dementia |
22194595 |
The ?-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b). |
unassigned |
0 |
| 3.4.23.B24 | Glioblastoma |
28198167 |
Signal Peptide Peptidase, Encoded by HM13, Contributes to Tumor Progression by Affecting EGFRvIII Secretion Profiles in Glioblastoma. |
causal interaction
unassigned |
2
0 |
| 3.4.23.B24 | Hepatitis C |
8862403 |
Hepatitis C virus core protein: carboxy-terminal boundaries of two processed species suggest cleavage by a signal peptide peptidase. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
4
4
2
0 |
| 3.4.23.B24 | Hepatitis C |
15479818 |
Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells. |
ongoing research
therapeutic application
unassigned |
2
1
0 |
