EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.47 | Chronic Periodontitis |
11056401 |
Design and synthesis of sensitive fluorogenic substrates specific for Lys-gingipain. |
causal interaction
unassigned |
4
0 |
| 3.4.22.47 | Chronic Periodontitis |
17030507 |
Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure. |
causal interaction
therapeutic application
unassigned |
4
2
0 |
| 3.4.22.47 | Chronic Periodontitis |
22069588 |
Porphyromonas gingivalis Gingipains Trigger a Proinflammatory Response in Human Monocyte-derived Macrophages Through the p38? Mitogen-activated Protein Kinase Signal Transduction Pathway. |
therapeutic application
unassigned |
1
0 |
| 3.4.22.47 | Gingivitis |
11243579 |
Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin. |
ongoing research
unassigned |
4
0 |
| 3.4.22.47 | Gingivitis |
17462155 |
[Clinical association of gingipain K-caspase like subdomain expression of Porphyromonas gingivalis with puberty gingivitis] |
diagnostic usage
ongoing research
unassigned |
3
2
0 |
| 3.4.22.47 | Gingivitis |
25858379 |
[Detection of gingipain K in the gingival crevicular fluid of orthodontic patients]. |
therapeutic application
unassigned |
3
0 |
| 3.4.22.47 | Infections |
11292714 |
Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection. |
ongoing research
therapeutic application
unassigned |
3
2
0 |
| 3.4.22.47 | Infections |
25266723 |
Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis. |
unassigned |
0 |
| 3.4.22.47 | Neoplasms |
24755218 |
Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-? and interleukin-1? but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain. |
unassigned |
0 |
| 3.4.22.47 | Periodontal Diseases |
9538207 |
Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease. |
causal interaction
diagnostic usage
unassigned |
4
1
0 |
