EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.21.45 | Alzheimer Disease |
29782502 |
A monoclonal antibody targeting amyloid ? (A?) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer's disease. |
ongoing research
therapeutic application
unassigned |
1
2
0 |
| 3.4.21.45 | Angioedema |
6762276 |
The role of complement in urticaria and angioedema. |
therapeutic application
unassigned |
3
0 |
| 3.4.21.45 | Arthritis, Rheumatoid |
819459 |
C3b inactivator in the rheumatic diseases. Measurement by radial immunodiffusion and by inhibition of formation of properdin pathway C3 convertase. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
1
4
1
0 |
| 3.4.21.45 | Arthritis, Rheumatoid |
6158571 |
Alternative pathway complement activation in rheumatoid arthritis. |
diagnostic usage
unassigned |
2
0 |
| 3.4.21.45 | Arthritis, Rheumatoid |
6903558 |
Increased biosynthesis of complement components by cultured monocytes, synovial fluid macrophages and skynovial membrane cells from patients with rheumatoid arthritis. |
diagnostic usage
ongoing research
unassigned |
3
2
0 |
| 3.4.21.45 | Atypical Hemolytic Uremic Syndrome |
15917334 |
Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome. |
causal interaction
unassigned |
4
0 |
| 3.4.21.45 | Atypical Hemolytic Uremic Syndrome |
19877009 |
Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead either to altered secretion or altered function of factor I. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.4.21.45 | Atypical Hemolytic Uremic Syndrome |
20118898 |
Excessive activation of the complement system in atypical hemolytic uremic syndrome: is it ready for prime time? |
causal interaction
unassigned |
4
0 |
| 3.4.21.45 | Atypical Hemolytic Uremic Syndrome |
24034049 |
A Newly Identified Mutation in the Complement Factor I Gene Not Associated With Early Post-transplant Recurrence of Atypical Hemolytic-Uremic Syndrome: A Case Report. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.4.21.45 | Atypical Hemolytic Uremic Syndrome |
26541438 |
Eculizumab for the treatment of an atypical hemolytic uremic syndrome with mutations in complement factor I and C3. |
therapeutic application
unassigned |
4
0 |
