EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   2.7.11.23 | Neoplasms |
18785202 |
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
3
1 |
| 2.7.11.23 | Cardiomegaly |
19246988 |
7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor. |
unassigned |
0 |
| 2.7.11.23 | Neoplasms |
25492483 |
7SK small nuclear RNA inhibits cancer cell proliferation through apoptosis induction. |
ongoing research
unassigned |
4
0 |
| 2.7.11.23 | Neoplasms |
27752877 |
7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells. |
unassigned |
0 |
| 2.7.11.23 | Xeroderma Pigmentosum |
8663148 |
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. |
unassigned |
0 |
| 2.7.11.23 | Neoplasms |
21552262 |
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. |
therapeutic application
unassigned |
4
0 |
| 2.7.11.23 | Ataxia Telangiectasia |
27100743 |
A critical role for topoisomerase IIb and DNA double strand breaks in transcription. |
causal interaction
unassigned |
1
0 |
| 2.7.11.23 | Neoplasms |
25431422 |
A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. |
therapeutic application
unassigned |
1
0 |
| 2.7.11.23 | Neoplasms |
33230210 |
A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours. |
ongoing research
therapeutic application
unassigned |
2
3
0 |
| 2.7.11.23 | Ataxia Telangiectasia |
26779995 |
A flow cytometry assay that measures cellular sensitivity to DNA-damaging agents, customized for clinical routine laboratories. |
diagnostic usage
unassigned |
3
0 |
