EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   2.7.11.11 | Neoplasms |
23539442 |
"NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors." |
causal interaction
diagnostic usage
unassigned |
4
3
0 |
| 2.7.11.11 | Whooping Cough |
29883692 |
17?-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor. |
unassigned |
0 |
| 2.7.11.11 | Neoplasms |
22867812 |
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells. |
unassigned |
0 |
| 2.7.11.11 | Carcinoma, Hepatocellular |
28356961 |
2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
1
4
0 |
| 2.7.11.11 | Neoplasms |
26917778 |
4EBP1/c-MYC/PUMA and NF?B/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.7.11.11 | Bradycardia |
10564147 |
5-HT(4) receptors in nucleus tractus solitarii attenuate cardiopulmonary reflex in anesthetized rats. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
1
1
3
0 |
| 2.7.11.11 | Adrenocortical Adenoma |
26684645 |
5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer. |
causal interaction
unassigned |
1
0 |
| 2.7.11.11 | Neoplasms |
1688548 |
8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation. |
unassigned |
0 |
| 2.7.11.11 | Neoplasms |
9815703 |
8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer. |
causal interaction
ongoing research
unassigned |
4
3
0 |
| 2.7.11.11 | Leukemia |
8449943 |
8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. |
causal interaction
ongoing research
unassigned |
1
3
0 |
