EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
   2.4.1.223 | Neoplasms |
10318803 |
The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. |
causal interaction
unassigned |
1
0 |
| 2.4.1.223 | Exostoses, Multiple Hereditary |
11121397 |
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. |
causal interaction
unassigned |
1
0 |
| 2.4.1.223 | Neoplasms |
11121397 |
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. |
causal interaction
unassigned |
1
0 |
| 2.4.1.223 | Adenocarcinoma |
11382776 |
A novel endo-beta-galactosidase from Clostridium perfringens that liberates the disaccharide GlcNAcalpha 1-->Gal from glycans specifically expressed in the gastric gland mucous cell-type mucin. |
ongoing research
unassigned |
1
0 |
| 2.4.1.223 | Stomach Neoplasms |
12594234 |
Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer. |
diagnostic usage
unassigned |
4
0 |
| 2.4.1.223 | Pancreatic Neoplasms |
16441422 |
Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. |
causal interaction
diagnostic usage
ongoing research
unassigned |
1
4
3
0 |
| 2.4.1.223 | Exostoses, Multiple Hereditary |
17237233 |
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. |
causal interaction
ongoing research
unassigned |
1
1
0 |
| 2.4.1.223 | Neoplasms |
17237233 |
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. |
causal interaction
ongoing research
unassigned |
1
1
0 |
| 2.4.1.223 | Mucopolysaccharidoses |
19690583 |
Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses. |
therapeutic application
unassigned |
4
0 |
| 2.4.1.223 | Mucopolysaccharidosis III |
19690583 |
Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses. |
therapeutic application
unassigned |
4
0 |
