EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   2.3.1.286 | Diabetic Cardiomyopathies |
28714516 |
(-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions. |
causal interaction
unassigned |
3
0 |
| 2.3.1.286 | Insulin Resistance |
23880847 |
(Healthy) ageing: focus on iodothyronines. |
causal interaction
unassigned |
3
0 |
| 2.3.1.286 | Metabolic Diseases |
23880847 |
(Healthy) ageing: focus on iodothyronines. |
causal interaction
unassigned |
3
0 |
| 2.3.1.286 | Obesity |
23880847 |
(Healthy) ageing: focus on iodothyronines. |
causal interaction
unassigned |
3
0 |
| 2.3.1.286 | Arthritis, Rheumatoid |
27763638 |
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 2.3.1.286 | Neoplasms |
27763638 |
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 2.3.1.286 | Heart Diseases |
27561793 |
1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy and fibrosis through PARP1/SIRT1/mTOR related mechanisms in Type 1 diabetes. |
causal interaction
diagnostic usage
unassigned |
4
2
0 |
| 2.3.1.286 | Neoplasms |
26689352 |
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells. |
ongoing research
unassigned |
2
0 |
| 2.3.1.286 | Cardiomegaly |
30856082 |
1.25 Dihydroxyvitamin D3 Attenuates Hypertrophy Markers in Cardiomyoblast H9c2 Cells: Evaluation of Sirtuin3 mRNA and Protein Level. |
diagnostic usage
ongoing research
unassigned |
1
3
0 |
| 2.3.1.286 | Hypertension |
30227325 |
15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
