EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category  |
Confidence Level |
|---|
    1.5.5.2 | Breast Neoplasms |
31189611 |
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 1.5.5.2 | Breast Neoplasms |
31559416 |
HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer. |
causal interaction
unassigned |
2
0 |
| 1.5.5.2 | Neoplasms |
17992665 |
Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
3
3
0 |
| 1.5.5.2 | Neoplasms |
22885468 |
Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment. |
causal interaction
unassigned |
3
0 |
| 1.5.5.2 | Neoplasms |
22886911 |
Proline dehydrogenase (oxidase) in cancer. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 1.5.5.2 | Neoplasms |
34283310 |
Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
2
3
2 |
| 1.5.5.2 | Nervous System Diseases |
24218577 |
Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH. |
causal interaction
diagnostic usage
unassigned |
1
3
0 |
| 1.5.5.2 | DiGeorge Syndrome |
15494707 |
Hyperprolinemia is a risk factor for schizoaffective disorder. |
causal interaction
diagnostic usage
unassigned |
3
1
0 |
| 1.5.5.2 | Neoplasms |
34089390 |
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
2
3
2 |
| 1.5.5.2 | Brain Neoplasms |
34089390 |
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
2
3
2 |
