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EC Number	Disease	PubMed ID	Title of Publication	Category	Confidence Level
3.5.3.1	Aberrant Crypt Foci	22982865	Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-?1and HES-1 transcripts in 1, 2-dimethylhydrazine-colon carcinogenesis in mice.	therapeutic application unassigned	1 0
3.5.3.1	Acidosis	33743287	Long lasting protective effects of early l-arginine treatment on endothelium in an in vitro study.	ongoing research unassigned	3 0
3.5.3.1	Acute Kidney Injury	16825094	Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats.	causal interaction ongoing research unassigned	2 3 0
3.5.3.1	Acute Lung Injury	20938379	Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity.	causal interaction diagnostic usage unassigned	4 3 0
3.5.3.1	Acute Lung Injury	23966993	Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.	causal interaction diagnostic usage ongoing research therapeutic application	4 3 1 1
3.5.3.1	Adenocarcinoma	1643605	Clinical significance of arginase in colorectal cancer.	causal interaction diagnostic usage ongoing research unassigned	4 4 2 0
3.5.3.1	Adenocarcinoma	8797936	Immunohistochemical study of arginase in cancer of the stomach.	causal interaction diagnostic usage ongoing research unassigned	4 3 4 0
3.5.3.1	Adenocarcinoma	11249934	Arginase isoforms in human colorectal cancer.	causal interaction diagnostic usage ongoing research unassigned	1 4 4 0
3.5.3.1	Adenocarcinoma	12011984	Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.	causal interaction ongoing research therapeutic application unassigned	1 3 2 0
3.5.3.1	Adenocarcinoma	13489701	Arginase activity and nucleic acid content in mamary adenocarcinoma and normal homologous tissue of C3H mice.	ongoing research unassigned	4 0
3.5.3.1	Adenocarcinoma	16935537	Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.	causal interaction ongoing research unassigned	4 1 0
3.5.3.1	Adenocarcinoma	22434791	Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and glypican-3 in fine-needle aspiration biopsies.	ongoing research unassigned	2 0
3.5.3.1	Adenocarcinoma	22848265	Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas.	causal interaction diagnostic usage ongoing research therapeutic application	1 3 2 1
3.5.3.1	Adenocarcinoma	24281232	Arginase-1: a highly specific marker separating pancreatic adenocarcinoma from hepatocellular carcinoma.	causal interaction diagnostic usage unassigned	2 3 0
3.5.3.1	Adenocarcinoma	24541334	Inhibitory effects of arginase on mammary adenocarcinoma transplants in strain "A" mice.	ongoing research therapeutic application unassigned	4 2 0
3.5.3.1	Adenocarcinoma	24541335	Effects of adrenocorticotropic hormone (ACTH), cortisone, and arginase on growth of transplanted mammary adenocarcinoma in C3H mice.	ongoing research therapeutic application unassigned	4 1 0
3.5.3.1	Adenocarcinoma	25812766	Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.	ongoing research unassigned	4 0
3.5.3.1	Adenocarcinoma	26030248	HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region.	causal interaction diagnostic usage ongoing research therapeutic application	2 3 3 2
3.5.3.1	Adenocarcinoma	27137985	Arginase-1 is frequently positive in hepatoid adenocarcinomas.	causal interaction diagnostic usage unassigned	3 3 0
3.5.3.1	Adenocarcinoma	27184483	Hepatocyte differentiation markers in adenocarcinoma of the prostate: hepatocyte paraffin 1 but not arginase-1 is specifically expressed in a subset of prostatic adenocarcinoma.	causal interaction unassigned	3 0
3.5.3.1	Adenocarcinoma	28344866	CD13(hi) Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma.	causal interaction unassigned	1 0
3.5.3.1	Adenocarcinoma	29782949	Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.	diagnostic usage ongoing research unassigned	3 3 0
3.5.3.1	Adenocarcinoma	30784016	The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver.	causal interaction diagnostic usage ongoing research unassigned	3 4 3 0
3.5.3.1	Adenocarcinoma	32371580	DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization.	unassigned	0
3.5.3.1	Adenocarcinoma	32415175	Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells.	causal interaction ongoing research unassigned	1 2 0
3.5.3.1	Adenocarcinoma of Lung	30066894	Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models.	causal interaction therapeutic application unassigned	2 4 0
3.5.3.1	Adenocarcinoma of Lung	30728077	Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.	causal interaction diagnostic usage ongoing research therapeutic application	4 3 4 4
3.5.3.1	Adenocarcinoma of Lung	31051694	Arginase-1 and HepPar-1 expression in fine-needle aspiration specimens of primary lung adenocarcinoma.	causal interaction diagnostic usage ongoing research unassigned	1 4 2 0
3.5.3.1	Adenocarcinoma, Papillary	22848265	Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas.	causal interaction diagnostic usage ongoing research therapeutic application	1 3 2 1
3.5.3.1	Adenomyoma	32534705	Immunohistochemical results and case report of an incidental finding of uterine polypoid adenomyoma after long-time therapy for metrorrhagia.	unassigned	0
3.5.3.1	Adrenoleukodystrophy	8777806	[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]	causal interaction unassigned	3 0
3.5.3.1	Airway Obstruction	18583571	Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.	causal interaction therapeutic application unassigned	4 4 0
3.5.3.1	Airway Obstruction	20124949	Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.	causal interaction ongoing research therapeutic application unassigned	4 2 1 0
3.5.3.1	Airway Obstruction	24727374	Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD).	causal interaction unassigned	3 0
3.5.3.1	Albuminuria	25320354	Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.	ongoing research unassigned	4 0
3.5.3.1	Alopecia	18271400	[Clinical and biochemical alterations in rats treated with high doses of vitamin A]	causal interaction diagnostic usage unassigned	3 1 0
3.5.3.1	Alphavirus Infections	22972923	Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus.	causal interaction ongoing research therapeutic application unassigned	1 1 1 0
3.5.3.1	Alzheimer Disease	19099206	The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease.	causal interaction diagnostic usage ongoing research unassigned	4 4 4 0
3.5.3.1	Alzheimer Disease	26197808	Bioinformatics methods in drug repurposing for Alzheimer's disease.	causal interaction unassigned	2 0
3.5.3.1	Alzheimer Disease	31089055	L-Norvaline, a new therapeutic agent against Alzheimer's disease.	causal interaction unassigned	1 0
3.5.3.1	Alzheimer Disease	32046281	Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice.	causal interaction ongoing research unassigned	4 1 0
3.5.3.1	Alzheimer Disease	33811757	Alzheimer's disease as a chronic maladaptive polyamine stress response.	causal interaction therapeutic application unassigned	3 4 0
3.5.3.1	Alzheimer Disease	34046031	Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-? Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis.	causal interaction ongoing research therapeutic application unassigned	1 2 1 0
3.5.3.1	Amebiasis	31199070	Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.	causal interaction therapeutic application unassigned	3 4 0
3.5.3.1	amino-acid n-acetyltransferase deficiency	15164414	Genetic approach to prenatal diagnosis in urea cycle defects.	causal interaction unassigned	4 0
3.5.3.1	amino-acid n-acetyltransferase deficiency	27215558	Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.	causal interaction unassigned	4 0
3.5.3.1	Amyloidosis	33519806	Arginase 1 Insufficiency Precipitates Amyloid-? Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis.	unassigned	0
3.5.3.1	Amyotrophic Lateral Sclerosis	1983181	Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis.	diagnostic usage ongoing research unassigned	4 4 0
3.5.3.1	Amyotrophic Lateral Sclerosis	2429045	[Study of cerebrospinal fluid arginase activity in the diagnosis of amyotrophic lateral sclerosis]	diagnostic usage unassigned	4 0
3.5.3.1	Amyotrophic Lateral Sclerosis	24655927	Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase.	ongoing research therapeutic application unassigned	1 1 0
3.5.3.1	Amyotrophic Lateral Sclerosis	29408267	Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis.	causal interaction therapeutic application unassigned	1 1 0
3.5.3.1	Anaplasmosis	2763451	Enzymes of oxidant defence system of leucocytes and erythrocytes in bovine anaplasmosis.	unassigned	0
3.5.3.1	Anemia	9863373	[Arginase activity in plasma and erythrocytes in children with hematologic diseases]	causal interaction diagnostic usage ongoing research unassigned	3 3 4 0
3.5.3.1	Anemia	20405289	Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.	diagnostic usage unassigned	2 0
3.5.3.1	Anemia	26041418	Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.	causal interaction ongoing research unassigned	1 4 0
3.5.3.1	Anemia, Hemolytic	9863373	[Arginase activity in plasma and erythrocytes in children with hematologic diseases]	causal interaction diagnostic usage ongoing research unassigned	3 3 4 0
3.5.3.1	Anemia, Hypochromic	16658052	Mode of Action of the Toxin from Pseudomonas phaseolicola: I. Toxin Specificity, Chlorosis, and Ornithine Accumulation.	therapeutic application unassigned	1 0
3.5.3.1	Anemia, Pernicious	13439269	The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major.	ongoing research unassigned	1 0
3.5.3.1	Anemia, Sickle Cell	15998894	Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.	causal interaction diagnostic usage ongoing research unassigned	4 4 2 0
3.5.3.1	Anemia, Sickle Cell	16225659	Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy.	causal interaction diagnostic usage therapeutic application unassigned	4 1 1 0
3.5.3.1	Anemia, Sickle Cell	16291595	Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.	causal interaction diagnostic usage therapeutic application unassigned	4 4 1 0
3.5.3.1	Anemia, Sickle Cell	16339702	Hemolysis-associated pulmonary hypertension in thalassemia.	unassigned	0
3.5.3.1	Anemia, Sickle Cell	17353439	Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.	causal interaction therapeutic application unassigned	4 4 0
3.5.3.1	Anemia, Sickle Cell	17897312	In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes.	causal interaction therapeutic application unassigned	4 4 0
3.5.3.1	Anemia, Sickle Cell	18762165	Cysteine-iron promotes arginase activity by driving the Fenton reaction.	causal interaction unassigned	4 0
3.5.3.1	Anemia, Sickle Cell	19073155	Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway.	causal interaction unassigned	3 0
3.5.3.1	Anemia, Sickle Cell	20089363	Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.	causal interaction diagnostic usage therapeutic application unassigned	3 1 4 0
3.5.3.1	Anemia, Sickle Cell	20405289	Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.	diagnostic usage unassigned	2 0
3.5.3.1	Anemia, Sickle Cell	26041418	Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.	causal interaction ongoing research unassigned	1 4 0
3.5.3.1	Anemia, Sickle Cell	27274608	Influence of ?S-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease.	causal interaction ongoing research unassigned	1 3 0
3.5.3.1	Anemia, Sickle Cell	27537757	Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.	causal interaction ongoing research therapeutic application unassigned	2 3 1 0
3.5.3.1	Anemia, Sideroblastic	1179163	A case of sideroblastic anaemia associated with marked elevation of erythrocytic arginase activity.	causal interaction unassigned	3 0
3.5.3.1	Angina Pectoris	1139781	Early diagnosis of myocardial infarction by arginase activity determination.	causal interaction diagnostic usage therapeutic application unassigned	2 4 1 0
3.5.3.1	Aortic Aneurysm, Abdominal	30792060	Transforming growth factor ? neutralization finely tunes macrophage phenotype in elastase-induced abdominal aortic aneurysm and is associated with an increase of arginase 1 expression in the aorta.	unassigned	0
3.5.3.1	arginase deficiency	164740	Unsuccessful trial of gene replacement in arginase deficiency.	ongoing research therapeutic application unassigned	2 1 0
3.5.3.1	arginase deficiency	481955	Hyperargininemia with arginase deficiency.	causal interaction therapeutic application unassigned	3 2 0
3.5.3.1	arginase deficiency	624188	Arginase deficiency in multiple tissues in argininemia.	causal interaction unassigned	2 0
3.5.3.1	arginase deficiency	819629	Excretion of guanidino-derivates in urine of hyperargininemic patients.	unassigned	0
3.5.3.1	arginase deficiency	839368	Hyperargininemia.	causal interaction unassigned	4 0
3.5.3.1	arginase deficiency	845487	A simple screening test for arginase deficiency (hyperargininemia).	diagnostic usage therapeutic application unassigned	3 3 0
3.5.3.1	arginase deficiency	890993	A simple spot-test for the detection of erythrocyte arginase deficiency.	diagnostic usage unassigned	3 0
3.5.3.1	arginase deficiency	925998	Influence of arginase deficiency on amino acid concentrations in sheep erythrocytes with a normal and with a defective transport system for amino acids [proceedings]	ongoing research unassigned	2 0
3.5.3.1	arginase deficiency	1404883	[The dibasic amino acid metabolic disorders]	causal interaction unassigned	3 0
3.5.3.1	arginase deficiency	1598908	Molecular genetic study of human arginase deficiency.	causal interaction diagnostic usage ongoing research unassigned	4 3 4 0
3.5.3.1	arginase deficiency	2291040	[Late diagnosis of congenital argininemia during administration of sodium valproate]	causal interaction diagnostic usage therapeutic application unassigned	3 2 2 0
3.5.3.1	arginase deficiency	2657590	Hyperargininemia, epilepsy and the metabolism of guanidino compounds.	causal interaction unassigned	4 0
3.5.3.1	arginase deficiency	3104676	A new case of arginase deficiency in a Spanish male.	causal interaction ongoing research unassigned	1 1 0
3.5.3.1	arginase deficiency	3447498	[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]	causal interaction unassigned	4 0
3.5.3.1	arginase deficiency	3540926	Pteridines and mono-amines: relevance to neurological damage.	unassigned	0
3.5.3.1	arginase deficiency	3632278	Liver fibrosis in arginase deficiency.	causal interaction unassigned	4 0
3.5.3.1	arginase deficiency	3760903	Arginase deficiency and phenylketonuria.	unassigned	0
3.5.3.1	arginase deficiency	3936352	Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates.	causal interaction unassigned	1 0
3.5.3.1	arginase deficiency	3943226	A simple quantitative micromethod of arginase assay in blood spots dried on filter paper.	diagnostic usage unassigned	4 0
3.5.3.1	arginase deficiency	3950825	Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function.	causal interaction unassigned	2 0
3.5.3.1	arginase deficiency	4078590	Impaired neurotransmitter amine metabolism in arginase deficiency.	unassigned	0
3.5.3.1	arginase deficiency	4625814	Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver.	causal interaction unassigned	1 0
3.5.3.1	arginase deficiency	5438971	[Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies]	unassigned	0
3.5.3.1	arginase deficiency	5438972	[Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.]	unassigned	0
3.5.3.1	arginase deficiency	6404622	Isoenzyme pattern and immunological properties of arginase in normal and hyperargininemia fibroblasts.	ongoing research unassigned	2 0
3.5.3.1	arginase deficiency	6422160	A new French-Canadian family affected by hyperargininaemia.	causal interaction unassigned	4 0

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