EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
2.7.12.2 | 0.0000012 |
- |
4-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-3-hydroxy-4-oxobutanamide |
cascade IC50 |
681316 |
2.7.12.2 | 0.000004 |
- |
4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide |
colon26 cellular assay |
681316 |
2.7.12.2 | 0.000005 |
- |
4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide |
colon26 cellular assay |
681316 |
2.7.12.2 | 0.0000052 |
- |
CH4987655 |
inhibition of MEK1, pH and temperature not specified in the publication |
740419 |
2.7.12.2 | 0.0000068 |
0.000124 |
4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-one |
selective anthranilic acid type inhibitors, residues K97, I141, M143, F129, V127, I126, L118, F209, V211, and S212 of MEK1/2 are important for interaction with the inhibitor, noncompetitive to ATP, inhibition of ERK phosphorylation by MEK1/2 by the deriva |
665990 |
2.7.12.2 | 0.000014 |
- |
selumetinib |
inhibition of MEK1 phosphorylation of ERK2, pH and temperature not specified in the publication |
740419 |
2.7.12.2 | 0.000016 |
- |
CI-1040 |
clinical candidate, inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay |
681316 |
2.7.12.2 | 0.0000174 |
- |
3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide |
cascade IC50 |
681316 |
2.7.12.2 | 0.000018 |
- |
4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide |
cascade IC50 |
681316 |
2.7.12.2 | 0.000018 |
- |
4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide |
inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay |
681316 |