EC Number   |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Reference |
|---|
   3.1.4.35 | 0.0000026 |
- |
8-bromo-1-ethyl-3,7-dihydro-7-[(4-methoxyphenyl)methyl]-3-(2-methylpropyl)-1H-purine-2,6-dione |
30°C, pH 7.4, recombinant rod PDE6alphabeta |
667547 |
| 3.1.4.35 | 0.0000035 |
- |
E4021 |
30°C, pH 7.4, native PDE6 |
667547 |
| 3.1.4.35 | 0.0000036 |
- |
8-bromo-1-ethyl-3,7-dihydro-7-[(4-methoxyphenyl)methyl]-3-(2-methylpropyl)-1H-purine-2,6-dione |
30°C, pH 7.4, recombinant cone PDE6alpha' |
667547 |
| 3.1.4.35 | 0.0000045 |
- |
1,3-dimethyl-6-(2-propoxy-5-methanesulfonylamidophenyl)pyrazol[3,4d]-pyrimidin-4-(5H)-one |
sham-operated rats |
653083 |
| 3.1.4.35 | 0.000013 |
- |
sildenafil |
37°C, pH 7.4, recombinant isoenzyme PDE5A3 |
649549 |
| 3.1.4.35 | 0.000014 |
- |
sildenafil |
37°C, pH 7.4, recombinant isoenzyme PDE5A2 |
649549 |
| 3.1.4.35 | 0.0000173 |
- |
5-ethyl-7,8-dihydro-2,7(R)-bis(phenylmethyl)-1H-imidazo[2,1-b]purin-4(5H)-one |
30°C, pH 7.4, native PDE6 |
667547 |
| 3.1.4.35 | 0.0000183 |
- |
8-bromo-1-ethyl-3,7-dihydro-7-[(4-methoxyphenyl)methyl]-3-(2-methylpropyl)-1H-purine-2,6-dione |
30°C, pH 7.4, native PDE6 |
667547 |
| 3.1.4.35 | 0.0000245 |
- |
sildenafil |
30°C, pH 7.4, native PDE6 |
667547 |
| 3.1.4.35 | 0.000025 |
- |
sildenafil |
chimaeric PDE5/6 catalytic domain, pH and temperature not specified in the publication |
711849 |
