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EC Number	Cofactor	Commentary	Reference
2.8.4.4	S-adenosyl-L-methionine	-	737730, 738458
2.8.4.4	S-adenosyl-L-methionine	the enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes	724275
2.8.4.4	[4Fe-4S]-center	-	738458
2.8.4.4	[4Fe-4S]-center	contains two iron-sulfur clusters	737730
2.8.4.4	[4Fe-4S]-center	enzyme contains two [4Fe-4S] centers, one presumably bound to three invariant cysteines in the central radical S-adenosylmethionine domain and the other to three invariant cysteines in the N-terminal UPF0004 domain	727871

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Release 2023.1 (January 2023)