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EC Number	Cofactor	Commentary	Reference
1.12.99.6	more	iron-guanylylpyridinol	703728
1.12.99.6	NAD+	-	702254
1.12.99.6	[2Fe-2S]-center	-	743732
1.12.99.6	[3Fe-4S]-center	the enzyme contains three FeS clusters: a distal [4Fe-4S]2+/1+ center, a medial [3Fe-4S]1+/0 center and a proximal [4Fe-3S]5+/4+ center. The main reason for O2 tolerance is the presence of a special [4Fe-3S] cluster in the proximal position relative to the active site, which discharges a second electron when O2 attacks	764975
1.12.99.6	[4Fe-3S]-center	the enzyme contains three FeS clusters: a distal [4Fe-4S]2+/1+ center, a medial [3Fe-4S]1+/0 center and a proximal [4Fe-3S]5+/4+ center	764975
1.12.99.6	[4Fe-3S]-center	the unique [4Fe-3S] cluster is located in the small subunit	764154
1.12.99.6	[4Fe-4S]-center	-	743732
1.12.99.6	[4Fe-4S]-center	the enzyme contains three FeS clusters: a distal [4Fe-4S]2+/1+ center, a medial [3Fe-4S]1+/0 center and a proximal [4Fe-3S]5+/4+ center	764975

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Release 2023.1 (January 2023)