EC Number   |
Reference |
|---|
   3.1.3.67 | deletion of pten gene in the urothelium results in an increased susceptibility to chemically induced carcinogenesis |
694494 |
| 3.1.3.67 | expressed in Escherichia coli |
732810 |
| 3.1.3.67 | expression in Escherichia coli |
650767, 651881 |
| 3.1.3.67 | female pten-deficient +/- mice develop multifocal endometrial complex atypical hyperplasia between the age of 18 and 39 weeks |
694494 |
| 3.1.3.67 | fusion of a C-terminal truncated PTEN (amino acids 1-378) to Mycobacterium xenopi GyrA intein, and chitin-binding domain |
751061 |
| 3.1.3.67 | Generating of mice with a complete ablation of PTEN is achieved by crossing mice with a conditional point mutation of the pten gene with two transgenic strains in which Cre recmbinase is under the control of the probasin promoter. Mice with complete loss of PTEN in the prostate show 100% penetrance of invasive prostate cancer starting st the age of 6 month |
694494 |
| 3.1.3.67 | Generating of pten +/hyp mice that carry only one hypomorphic pten allele and thus expresses half of the wild type level of one wild type allele. Pten +/hyp mice are crossed with pten +/- mice to generate pten +/+, pten +/-, pten +/hyp and pten hyp/- mice. The pten hyp/- mice are not born at the expected Mendelian ratio, indicating that the hypomorphic pten allele is insufficient to rescue development in all embryos. Surviving male pten hyp/- mice have a much higher incidence of pathological changes in the prostate |
694494 |
| 3.1.3.67 | generating of Pten-deficient mice leads to an increasing rate of fatty acid synthesis that is 2.5 times higher than in wild types, furthermore an increase in insulin sensitivity in liver-specifiv Pten-deficient mice is observed, which results in lower fasting plasma glucose levels and reduced serum insulin |
694494 |
| 3.1.3.67 | Generating of thyroid-specific PTEN-deficient mice using TpoCre transgenic mice,PTEN deletion does not affect normal thyroid development and function, but may contribute to adenoma development |
694494 |
| 3.1.3.67 | generation of mice with conditional inactivation of PTEN in the mammary epithelium using two different MMTV-Cre recombinase mouse strains results in developmental defects of the mammary gland, mammary ducts in the mutant mice grow much faster than in wild type mice and exhibit excessive side branching and precocious lobuloalveolar budding |
694494 |
