   1.14.19.47 | investigation of the effects of these proteins on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhance polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity |
