1.14.19.47 - 1.14.19.47 expressed in Anabaena sp. 1.14.19.47 expressed in Arabidopsis thaliana 1.14.19.47 expressed in Aspergillus oryzae 1.14.19.47 expressed in HEK-293 cells 1.14.19.47 expressed in Nicotiana tabacum leaf and Arabidopsis thaliana seed 1.14.19.47 expressed in Pichia pastoris 1.14.19.47 expressed in Saccharomyces cerevisiae 1.14.19.47 expressed in Saccharomyces cerevisiae DBY746 cells 1.14.19.47 expressed in Saccharomyces cerevisiae strain W303-1A and Arabidopsis thaliana 1.14.19.47 expressed in Solanum lycopersicum 1.14.19.47 heterologous expression in yeast 1.14.19.47 heterologous expression of native and codon-optimized PyDes6 cDNAs in Saccharomyces cerevisiae 1.14.19.47 investigation of the effects of these proteins on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhance polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity