EC Number   |
Subunits |
Reference |
|---|
   3.4.21.B24 | ? |
x * 54000, SDS-APGE |
692581 |
| 3.4.21.B24 | ? |
x * about 58000, mature enzyme, SDS-PAGE |
718107 |
| 3.4.21.B24 | ? |
x * about 62000, mature enzyme, predicted from amino acid sequence |
718107 |
| 3.4.21.B24 | ? |
x * about 72000, pro-zymogen, SDS-PAGE |
718107 |
| 3.4.21.B24 | More |
PCSKs are biosynthesized in the endoplasmic reticulum as multidomain preproproteins consisting of an N-terminal signal peptide followed by a pro domain, a conserved catalytic domain, a P domain, and a variable C-terminal domain. After cotranslational removal of the signal peptide, the resulting proPCSK undergoes maturation by autocatalytic cleavage between the pro and the catalytic domains, within a cleavage motif that is also recognized by the fully activated enzyme in the primary sequence of its physiological substrates |
692581 |
| 3.4.21.B24 | More |
PCSKs are biosynthesized in the endoplasmic reticulum as multidomain preproproteins consisting of an N-terminal signal peptide followed by a pro domain, a conserved catalytic domain, a P domain, and a variable C-terminal domain. After cotranslational removal of the signal peptide, the resulting proPCSK undergoes maturation by autocatalytic cleavage between the pro and the catalytic domains, within a cleavage motif that is also recognized by the fully activated enzyme in the primary sequence of its physiological substrates. Domain structure, overview |
692581 |
