Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B24 extracted from

  • Gyamera-Acheampong, C.; Sirois, F.; Denis, N.J.; Mishra, P.; Figeys, D.; Basak, A.; Mbikay, M.
    The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone (2011), Mol. Cell. Biochem., 348, 43-52.
    View publication on PubMed
Search for more literature for 3.4.21.B24

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Mus musculus
expressed in HEK-293 cells Rattus norvegicus
expressed in HEK-293 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-
plasma membrane
-
 Rattus norvegicus 5886
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells ?
-
 ?
additional information Rattus norvegicus proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells ?
-
 ?
additional information Homo sapiens proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6UW60
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Mus musculus
glycoprotein
-
 Rattus norvegicus
glycoprotein glycosylation sites are at N465 and N629 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
germ cell
-
 Mus musculus
-
germ cell
-
 Rattus norvegicus
-
germ cell
-
 Homo sapiens
-
sperm
-
 Mus musculus
-
sperm
-
 Rattus norvegicus
-
sperm
-
 Homo sapiens
-
testis
-
 Mus musculus
-
testis
-
 Rattus norvegicus
-
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells Mus musculus ?
-
 ?
additional information proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells Rattus norvegicus ?
-
 ?
additional information proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * about 58000, mature enzyme, SDS-PAGE Homo sapiens
? x * about 62000, mature enzyme, predicted from amino acid sequence Mus musculus
? x * about 62000, mature enzyme, predicted from amino acid sequence Rattus norvegicus
? x * about 62000, mature enzyme, predicted from amino acid sequence Homo sapiens
? x * about 72000, pro-zymogen, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PC4
-
 Mus musculus
PC4
-
 Rattus norvegicus
PC4
-
 Homo sapiens
PCSK4
-
 Mus musculus
PCSK4
-
 Rattus norvegicus
PCSK4
-
 Homo sapiens
proprotein convertase subtilisin/kexin type 4
-
 Mus musculus
proprotein convertase subtilisin/kexin type 4
-
 Rattus norvegicus
proprotein convertase subtilisin/kexin type 4
-
 Homo sapiens