EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
    4.1.1.7 | benzaldehyde + benzaldehyde |
- |
Pseudomonas putida |
(2R)-2-hydroxy-1,2-diphenylethanone |
- |
? |
| 4.1.1.7 | o-methylbenzaldehyde + acetaldehyde |
mutant enzyme L476Q and M365L/L461S selectively catalyzes the formation of enantiopure (S)-2-hydroxy-1-(2-methylphenyl)propan-1-one with excellent yield, a reaction which is only poorly catalyzed by the wild-type enzyme |
Pseudomonas putida |
(2S)-2-hydroxy-1-(2-methylphenyl)propan-1-one |
- |
? |
| 4.1.1.7 | acetaldehyde + acetaldehyde |
- |
Pseudomonas putida |
(3R)-3-hydroxybutan-2-one |
- |
? |
| 4.1.1.7 | 2-fluorobenzaldehyde |
carboligation |
Pseudomonas putida |
(R)-1,2-Bis-(2-fluoro-phenyl)-2-hydroxy-ethanone |
68% yield and more than 99% enantiomeric excess of the (R)-enantiomer |
? |
| 4.1.1.7 | 4-bromobenzaldehyde |
carboligation |
Pseudomonas putida |
(R)-1,2-bis-(4-bromo-phenyl)-2-hydroxy-ethanone |
13% yield and more than 99% enantiomeric excess of the (R)-enantiomer |
? |
| 4.1.1.7 | 4-chlorobenzaldehyde |
carboligation |
Pseudomonas putida |
(R)-1,2-bis-(4-chloro-phenyl)-2-hydroxy-ethanone |
17% yield and more than 99% enantiomeric excess of the (R)-enantiomer |
? |
| 4.1.1.7 | 4-fluorobenzaldehyde |
carboligation |
Pseudomonas putida |
(R)-1,2-Bis-(4-fluoro-phenyl)-2-hydroxy-ethanone |
25% yield and more than 99% enantiomeric excess of the (R)-enantiomer |
? |
| 4.1.1.7 | 2-furaldehyde |
carboligation |
Pseudomonas putida |
(R)-1,2-di-furan-2-yl-2-hydroxy-ethanone |
62% yield and 94% enantiomeric excess of the (R)-enantiomer |
? |
| 4.1.1.7 | 3-methoxybenzaldehyde |
carboligation |
Pseudomonas putida |
(R)-2-Hydroxy-1,2-bis-(3-methoxy-phenyl)-ethanone |
18% yield and more than 99% enantiomeric excess of the (R)-enantiomer |
? |
| 4.1.1.7 | 4-methoxybenzaldehyde |
carboligation |
Pseudomonas putida |
(R)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethanone |
12% yield and more than 99% enantiomeric excess of the (R)-enantiomer |
? |
