EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.6.1.17 | (2'-pdA)AppppA + H2O |
cleavage to produce ATP and 2'-deoxyadenylated AMP rather than 2'-deoxyadenylated ATP + AMP occurs with a ratio of 60:40 with the wild-type enzyme and the mutant enzymes R54Q, E58D and E125Q. With the mutants R54Q, E58D and E125Q, releasing ATP is increased to 70% of total hydrolysis. Activity of mutants E55Q, E59D and E59Q is to low to be detected |
Lupinus angustifolius |
? |
- |
? |
3.6.1.17 | 2'-deoxyadenosine adenosine tetraphosphate + H2O |
- |
Homo sapiens |
ATP + 2'-dAMP + 2'-dATP + AMP |
80% dAMP, 20% AMP |
? |
3.6.1.17 | 2-oxo-dATP + H2O |
less efficient hydrolysis compared to 8-oxo-dGTP |
Caenorhabditis elegans |
? |
- |
? |
3.6.1.17 | 2-oxo-dATP + H2O |
less efficient hydrolysis compared to 8-oxo-dGTP |
Caenorhabditis elegans Bristol N2 |
? |
- |
? |
3.6.1.17 | 5',5''-diadenosine pentaphosphate + H2O |
- |
Plasmodium falciparum |
ATP + ADP |
42% of the activity with 5',5''-diadenosine tetraphosphate |
? |
3.6.1.17 | 5',5''-diadenosine tetraphosphate + H2O |
- |
Plasmodium falciparum |
ATP + AMP |
- |
? |
3.6.1.17 | 5',5'-diadenosine hexaphosphate + H2O |
diadenosine hexaphosphate is efficiently hydrolysed to ATP only at pH 7.5 with 20 mM Mg2+ |
Drosophila melanogaster |
2 ATP |
- |
? |
3.6.1.17 | 5',5'-diadenosine pentaphosphate + H2O |
- |
Drosophila melanogaster |
ATP + ADP |
- |
? |
3.6.1.17 | 5',5'-diadenosine tetraphosphate + H2O |
- |
Drosophila melanogaster |
ATP + AMP |
- |
? |
3.6.1.17 | 5',5'-diadenosine tetraphosphate + H2O |
best substrate |
Drosophila melanogaster |
ATP + AMP |
- |
? |