EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.5.4.36 | 5-methylcytosine in single-stranded DNA + H2O |
Apobec1 has 5-methylcytosine deaminase activity, resulting in a thymine base opposite a guanine. If this mismatch is repaired, a methylated cytosine is replaced by an unmethylated one. If it is not repaired, it results in a cytosine -> thymine transition mutation. Apobec1, and perhaps other members of this protein family play a role in epigenetic reprogramming |
Rattus norvegicus |
thymine in single-stranded DNA + NH3 |
- |
? |
3.5.4.36 | cytosine in RNA + H2O |
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo |
Mus musculus |
uracil in RNA + NH3 |
- |
? |
3.5.4.36 | cytosine in RNA + H2O |
transcriptome-wide sequencing reveals numerous APOBEC1 mRNA editing targets in transcript 3' untranslated regions, a molecular mechanism that suggests additional roles for APOBEC1 beyond its function in apolipoprotein regulation |
Mus musculus |
uracil in RNA + NH3 |
- |
? |
3.5.4.36 | cytosine in RNA + H2O |
APOBEC1 site-specifically edits many mRNA transcripts other than apoB in small intestine enterocytes. Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA editing targets in transcript 3' untranslated regions |
Mus musculus |
uracil in RNA + NH3 |
- |
? |
3.5.4.36 | cytosine in RNA + H2O |
murine APOBEC1 is able to hyperdeaminate cytidine residues in murine leukemia virus genomic RNA. In vitro murine APOBEC1 can extensively edit viral RNA, while human APOBEC1 cannot |
Mus musculus |
uracil in RNA + NH3 |
- |
? |
3.5.4.36 | cytosine in single-stranded DNA + H2O |
murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo |
Mus musculus |
uracil in single-stranded DNA + NH3 |
- |
? |
3.5.4.36 | cytosine in single-stranded DNA + H2O |
ssDNA hyperediting of an infectious exogenous gammaretrovirus, the Friendmurine leukemia virus, by murine APOBEC1 |
Mus musculus |
uracil in single-stranded DNA + NH3 |
- |
? |
3.5.4.36 | cytosine in single-stranded DNA + H2O |
when expressed in bacteria, APOBEC1 can deaminate cytosine in DNA. Its activity on DNA is specific for single-stranded DNA and exhibits dependence on local sequence context |
Rattus norvegicus |
uracil in single-stranded DNA + NH3 |
- |
? |
3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
- |
Homo sapiens |
uracil6666 in apolipoprotein B mRNA + NH3 |
- |
? |
3.5.4.36 | cytosine6666 in apolipoprotein B mRNA + H2O |
- |
Mus musculus |
uracil6666 in apolipoprotein B mRNA + NH3 |
- |
? |