EC Number   |
Substrates |
Organism |
Products |
Reversibility  |
|---|
   2.7.7.86 | more |
interaction of cGAS and viral DNA sensor IFI16, the pyrin domain of IFI16 mediates the interaction with ND10 bodies and enzyme cGAS |
Homo sapiens |
? |
- |
- |
| 2.7.7.86 | more |
a diphosphatase-coupled cGAS activity assay is performed |
Homo sapiens |
? |
- |
- |
| 2.7.7.86 | more |
quantification of cyclic Gp(2'-5')Ap(3'-5')(2',3'-cGAMP)WS is performed by LC-MS/MS |
Homo sapiens |
? |
- |
- |
| 2.7.7.86 | more |
the substrate orientation is thermodynamically preferred for 2',3'-cGAMP, kinetics, overview. cGAS can produce 2',3'-cGAMP without releasing AMP-2'-GTP to solution. AMP-2'-GTP is produced in significant abundance initially, while 2',3'-cGAMP is not |
Homo sapiens |
? |
- |
- |
| 2.7.7.86 | ATP + GTP |
- |
Homo sapiens |
2 diphosphate + cyclic 3',5'-AMP-GMP |
- |
? |
| 2.7.7.86 | ATP + GTP |
- |
Mus musculus |
2 diphosphate + cyclic 3',5'-AMP-GMP |
- |
? |
| 2.7.7.86 | ATP + GTP |
cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines |
Homo sapiens |
2 diphosphate + cyclic 3',5'-AMP-GMP |
- |
? |
| 2.7.7.86 | ATP + GTP |
cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines |
Mus musculus |
2 diphosphate + cyclic 3',5'-AMP-GMP |
- |
? |
| 2.7.7.86 | ATP + GTP |
- |
Homo sapiens |
2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') |
- |
? |
| 2.7.7.86 | ATP + GTP |
- |
Homo sapiens |
2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') |
product is cyclic Gp(2'-5')Ap(3'-5') |
? |
