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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136more structure-based substrate specificity, macrolide binding analysis, overview. Although erythromycin, clarithromycin, oleandomycin, and azithromycin differ in the size of the lactone ring and varying substitutions, the 14- and 15-membered ring substrates bind to the two MPH enzymes in a similar location, adopt similar conformations, and interact with the enzymes in a similar manner. MPH(2')-I cannot modify 16-membered macrolides, in contrast to MPH(2')-II Escherichia coli ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136more structure-based substrate specificity, macrolide binding analysis, overview. Although erythromycin, clarithromycin, oleandomycin, and azithromycin differ in the size of the lactone ring and varying substitutions, the 14- and 15-membered ring substrates bind to the two MPH enzymes in a similar location, adopt similar conformations, and interact with the enzymes in a similar manner. Unlike MPH(2')-I, MPH(2')-II can efficiently modify 16-membered macrolides. The 16-membered rings are more ovoid in shape compared with the rounded shape of the 14- and 15-membered macrolides. The interactions between MPH(2')-II and the 16-membered macrolides, spiramycin and josamycin, are similar to those of the 14- and 15-membered macrolides, involving many of the same amino acid side chains Escherichia coli ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin - Escherichia coli ADP + azithromycin 2'-O-phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin - uncultured bacterium ADP + azithromycin 2'-O-phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin 15% of the activity with oleandomycin Pseudomonas aeruginosa ADP + azithromycin 2'-O-phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin 15-membered ring macrolide Escherichia coli ADP + azithromycin 2'-O-phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin the mph(A) gene conferrs resistance to azithromycin Escherichia coli ADP + azithromycin 2'-O-phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin the mph(A) gene conferrs resistance to azithromycin Salmonella enterica subsp. enterica serovar Typhimurium ADP + azithromycin 2'-O-phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin the mph(A) gene conferrs resistance to azithromycin uncultured bacterium ADP + azithromycin 2'-O-phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.136ATP + azithromycin recombinant expression of the pRSB111 plasmid in Pseudomonas sp. strain B13 uncultured bacterium ADP + azithromycin 2'-O-phosphate - ?
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