EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.5.1.58 | (2E,6E)-farnesyl diphosphate + KGCVIM |
- |
Aspergillus fumigatus |
S-(2E,6E)-farnesyl-KGCVIM + diphosphate |
- |
? |
2.5.1.58 | (2E,6E)-farnesyl diphosphate + KGCVVM |
- |
Aspergillus fumigatus |
S-(2E,6E)-farnesyl-KGCVVM + diphosphate |
- |
? |
2.5.1.58 | (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine |
- |
Aspergillus fumigatus |
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate |
- |
? |
2.5.1.58 | (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine |
the reaction is catalyzed by protein farnesyltransferase on protein substrates bearing the C-terminal CaaX motif |
Aspergillus fumigatus |
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate |
- |
? |
2.5.1.58 | farnesyl diphosphate + protein-cysteine |
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln |
Bos taurus |
diphosphate + S-farnesyl protein |
- |
? |
2.5.1.58 | farnesyl diphosphate + protein-cysteine |
substrate: Ras-CVIM and GST-PEP |
Bos taurus |
diphosphate + S-farnesyl protein |
- |
? |
2.5.1.58 | farnesyl diphosphate + Ras-Cys-Val-Ile-Met |
- |
Bos taurus |
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met |
- |
? |
2.5.1.58 | (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine |
- |
Candida albicans |
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate |
- |
? |
2.5.1.58 | more |
protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview |
Candida albicans |
? |
- |
? |
2.5.1.58 | farnesyl diphosphate + protein-cysteine |
- |
Catharanthus roseus |
diphosphate + S-farnesyl protein |
- |
? |