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Information on EC 2.5.1.58 - protein farnesyltransferase

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IUBMB Comments
This enzyme, along with protein geranylgeranyltransferase types I (EC 2.5.1.59) and II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fptase, farnesyl protein transferase, pftase, prenyl transferase, protein farnesyl transferase, ras farnesyltransferase, protein prenyltransferase, caax farnesyltransferase, hftase, pf-pft, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
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