EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.4.1.22 | more |
acceptor substrate specificity, overview |
Bos taurus |
? |
- |
? |
2.4.1.22 | more |
upon substrate binding to beta4Gal-T1, a large conformational change occurs in the region comprising residues 345 to 365. The role of alpha-lactalbumin is to hold glucose by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the glucose molecule |
Mus musculus |
? |
- |
? |
2.4.1.22 | more |
upon substrate binding to beta4Gal-T1, a large conformational change occurs in the region comprising residues 345 to 365. The role of alpha-lactalbumin is to hold glucose by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the glucose molecule |
Bos taurus |
? |
- |
? |
2.4.1.22 | more |
acceptor substrate specificity, no activity with D-galactose, N-acetylgalactosamine, glucosamine, and lactose as acceptor substrates, no activity with UDP-glucose as donor substrate, overview |
Helicobacter pylori |
? |
- |
? |
2.4.1.22 | more |
acceptor substrate specificity, no activity with D-galactose, N-acetylgalactosamine, glucosamine, and lactose as acceptor substrates, overview |
Neisseria meningitidis |
? |
- |
? |
2.4.1.22 | more |
molecular interaction with different donor substrates, overview, the enzyme undergoes transition from open to close conformation upon binding of donor or acceptor substrate, overview |
Bos taurus |
? |
- |
? |
2.4.1.22 | more |
beta1,4-galactosyltransferase-I forms a complex with alpha-lactalbumin to give lactose synthase |
Sus scrofa |
? |
- |
? |
2.4.1.22 | more |
c-LacdiNAcS is auto-lacdiNAcylated and can synthesize GalNAc(beta1-4)GlcNAc structures on cellular glycoproteins |
Bos taurus |
? |
- |
? |
2.4.1.22 | more |
the enzyme interacts with UDP-galactose transporter SLC35A2 |
Homo sapiens |
? |
- |
- |
2.4.1.22 | UDPgalactose + alpha-methyl-D-glucose |
- |
Mammalia |
? |
- |
? |