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(S)-propane-1,2-diol degradation
-
-
3-methylbutanol biosynthesis (engineered)
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-
acetaldehyde biosynthesis I
-
-
acetylene degradation (anaerobic)
-
-
alpha-Linolenic acid metabolism
-
-
Biosynthesis of secondary metabolites
-
-
butanol and isobutanol biosynthesis (engineered)
-
-
chitin degradation to ethanol
-
-
Chloroalkane and chloroalkene degradation
-
-
Drug metabolism - cytochrome P450
-
-
ethanol degradation I
-
-
ethanol degradation II
-
-
ethanolamine utilization
-
-
Fatty acid degradation
-
-
Glycine, serine and threonine metabolism
-
-
Glycolysis / Gluconeogenesis
-
-
heterolactic fermentation
-
-
L-isoleucine degradation II
-
-
L-leucine degradation III
-
-
L-methionine degradation III
-
-
L-phenylalanine degradation III
-
-
L-tryptophan degradation V (side chain pathway)
-
-
L-tyrosine degradation III
-
-
L-valine degradation II
-
-
Metabolism of xenobiotics by cytochrome P450
-
-
methionine metabolism
-
-
Microbial metabolism in diverse environments
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-
mixed acid fermentation
-
-
Naphthalene degradation
-
-
noradrenaline and adrenaline degradation
-
-
phenylalanine metabolism
-
-
phenylethanol biosynthesis
-
-
pyruvate fermentation to ethanol I
-
-
pyruvate fermentation to ethanol II
-
-
pyruvate fermentation to ethanol III
-
-
pyruvate fermentation to isobutanol (engineered)
-
-
salidroside biosynthesis
-
-
serotonin degradation
-
-
superpathway of fermentation (Chlamydomonas reinhardtii)
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-
Caprolactam degradation
-
-
detoxification of reactive carbonyls in chloroplasts
-
-
ethylene glycol biosynthesis (engineered)
-
-
Glycerolipid metabolism
-
-
L-tryptophan degradation X (mammalian, via tryptamine)
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-
Pentose and glucuronate interconversions
-
-
pyruvate fermentation to butanol I
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-
traumatin and (Z)-3-hexen-1-yl acetate biosynthesis
-
-
1,3-propanediol biosynthesis (engineered)
-
-
glycerol-3-phosphate shuttle
-
-
Glycerophospholipid metabolism
-
-
phosphatidate biosynthesis (yeast)
-
-
chorismate biosynthesis from 3-dehydroquinate
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-
chorismate metabolism
-
-
Phenylalanine, tyrosine and tryptophan biosynthesis
-
-
(S)-lactate fermentation to propanoate, acetate and hydrogen
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-
Bifidobacterium shunt
-
-
Cysteine and methionine metabolism
-
-
L-lactaldehyde degradation
-
-
Propanoate metabolism
-
-
pyruvate fermentation to (S)-lactate
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-
superpathway of glucose and xylose degradation
-
-
L-alanine degradation II (to D-lactate)
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-
vancomycin resistance I
-
-
isoprene biosynthesis II (engineered)
-
-
mevalonate metabolism
-
-
mevalonate pathway II (archaea)
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mevalonate pathway III (archaea)
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-
Terpenoid backbone biosynthesis
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-
anaerobic energy metabolism (invertebrates, cytosol)
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-
C4 and CAM-carbon fixation
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-
C4 photosynthetic carbon assimilation cycle, NAD-ME type
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Carbon fixation in photosynthetic organisms
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Carbon fixation pathways in prokaryotes
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Citrate cycle (TCA cycle)
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formaldehyde assimilation I (serine pathway)
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Glyoxylate and dicarboxylate metabolism
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incomplete reductive TCA cycle
-
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malate/L-aspartate shuttle pathway
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methylaspartate cycle
-
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partial TCA cycle (obligate autotrophs)
-
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pyruvate fermentation to propanoate I
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-
reductive TCA cycle I
-
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reductive TCA cycle II
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superpathway of glyoxylate cycle and fatty acid degradation
-
-
TCA cycle I (prokaryotic)
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TCA cycle II (plants and fungi)
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TCA cycle III (animals)
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TCA cycle IV (2-oxoglutarate decarboxylase)
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TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)
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anaerobic energy metabolism (invertebrates, mitochondrial)
-
-
L-carnitine degradation III
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-
L-malate degradation II
-
-
C4 photosynthetic carbon assimilation cycle, NADP-ME type
-
-
C4 photosynthetic carbon assimilation cycle, PEPCK type
-
-
L-glutamine biosynthesis III
-
-
Glutathione metabolism
-
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Pentose phosphate pathway
-
-
pentose phosphate pathway
-
-
pentose phosphate pathway (oxidative branch) I
-
-
Entner-Doudoroff pathway I
-
-
formaldehyde oxidation I
-
-
NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)
-
-
superpathway of glycolysis and the Entner-Doudoroff pathway
-
-
Primary bile acid biosynthesis
-
-
Steroid hormone biosynthesis
-
-
testosterone and androsterone degradation to androstendione
-
-
methylglyoxal degradation VI
-
-
isoleucine metabolism
-
-
L-isoleucine biosynthesis I (from threonine)
-
-
L-isoleucine biosynthesis III
-
-
L-valine biosynthesis
-
-
Pantothenate and CoA biosynthesis
-
-
Valine, leucine and isoleucine biosynthesis
-
-
Amino sugar and nucleotide sugar metabolism
-
-
Fructose and mannose metabolism
-
-
GDP-6-deoxy-D-talose biosynthesis
-
-
GDP-D-rhamnose biosynthesis
-
-
capsiconiate biosynthesis
-
-
phenylpropanoid biosynthesis
-
-
Phenylpropanoid biosynthesis
-
-
phenylpropanoid biosynthesis
-
-
adenosine nucleotides degradation I
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Drug metabolism - other enzymes
-
-
guanosine ribonucleotides de novo biosynthesis
-
-
inosine 5'-phosphate degradation
-
-
isoprenoid biosynthesis
-
-
methylerythritol phosphate pathway I
-
-
methylerythritol phosphate pathway II
-
-
formaldehyde oxidation
-
-
formaldehyde oxidation II (glutathione-dependent)
-
-
protein S-nitrosylation and denitrosylation
-
-
Ascorbate and aldarate metabolism
-
-
TCA cycle VI (Helicobacter)
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-
TCA cycle VII (acetate-producers)
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-
cellulose degradation
-
-
Arginine and proline metabolism
-
-
aromatic biogenic amine degradation (bacteria)
-
-
beta-Alanine metabolism
-
-
beta-methyl-branched fatty acid alpha-oxidation
-
-
ceramide and sphingolipid recycling and degradation (yeast)
-
-
ceramide degradation by alpha-oxidation
-
-
dimethylsulfoniopropanoate biosynthesis I (Wollastonia)
-
-
dimethylsulfoniopropanoate biosynthesis II (Spartina)
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-
Entner Doudoroff pathway
-
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Entner-Doudoroff pathway III (semi-phosphorylative)
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-
ethanol degradation III
-
-
ethanol degradation IV
-
-
fatty acid alpha-oxidation I (plants)
-
-
histamine degradation
-
-
hypotaurine degradation
-
-
Insect hormone biosynthesis
-
-
Limonene and pinene degradation
-
-
limonene degradation IV (anaerobic)
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-
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
-
-
putrescine degradation III
-
-
sphingosine and sphingosine-1-phosphate metabolism
-
-
Tryptophan metabolism
-
-
Valine, leucine and isoleucine degradation
-
-
3-dehydroquinate biosynthesis II (archaea)
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-
dipicolinate biosynthesis
-
-
grixazone biosynthesis
-
-
L-homoserine biosynthesis
-
-
L-lysine biosynthesis I
-
-
L-lysine biosynthesis II
-
-
L-lysine biosynthesis III
-
-
L-lysine biosynthesis VI
-
-
L-methionine biosynthesis IV (archaea)
-
-
Monobactam biosynthesis
-
-
norspermidine biosynthesis
-
-
spermidine biosynthesis II
-
-
formaldehyde assimilation III (dihydroxyacetone cycle)
-
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glycerol degradation to butanol
-
-
glycolysis I (from glucose 6-phosphate)
-
-
glycolysis II (from fructose 6-phosphate)
-
-
glycolysis III (from glucose)
-
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glycolysis IV (plant cytosol)
-
-
sucrose biosynthesis I (from photosynthesis)
-
-
Calvin-Benson-Bassham cycle
-
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4-aminobutanoate degradation III
-
-
Alanine, aspartate and glutamate metabolism
-
-
glutamate and glutamine metabolism
-
-
Nicotinate and nicotinamide metabolism
-
-
acetyl-CoA biosynthesis II (NADP-dependent pyruvate dehydrogenase)
-
-
oxidative decarboxylation of pyruvate
-
-
ethylene biosynthesis II (microbes)
-
-
L-arginine degradation I (arginase pathway)
-
-
L-proline degradation
-
-
2-oxoglutarate decarboxylation to succinyl-CoA
-
-
vitamin B1 metabolism
-
-
Entner-Doudoroff pathway II (non-phosphorylative)
-
-
gluconeogenesis II (Methanobacterium thermoautotrophicum)
-
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isopropanol biosynthesis (engineered)
-
-
L-glutamate degradation VII (to butanoate)
-
-
Nitrotoluene degradation
-
-
purine nucleobases degradation II (anaerobic)
-
-
pyruvate fermentation to acetate I
-
-
pyruvate fermentation to acetate III
-
-
pyruvate fermentation to acetate VI
-
-
pyruvate fermentation to acetate VII
-
-
pyruvate fermentation to acetone
-
-
pyruvate fermentation to butanoate
-
-
pyruvate fermentation to hexanol (engineered)
-
-
reductive monocarboxylic acid cycle
-
-
(5Z)-dodecenoate biosynthesis I
-
-
(5Z)-dodecenoate biosynthesis II
-
-
8-amino-7-oxononanoate biosynthesis I
-
-
arachidonate biosynthesis
-
-
cis-vaccenate biosynthesis
Fatty acid biosynthesis
-
-
fatty acid elongation -- saturated
-
-
gondoate biosynthesis (anaerobic)
-
-
mycolate biosynthesis
-
-
oleate biosynthesis IV (anaerobic)
-
-
palmitate biosynthesis
-
-
palmitate biosynthesis II (bacteria and plant cytoplasm)
-
-
palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
-
-
stearate biosynthesis II (bacteria and plants)
-
-
superpathway of mycolate biosynthesis
-
-
myristate biosynthesis (mitochondria)
-
-
octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)
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-
Pyrimidine metabolism
-
-
pyrimidine metabolism
-
-
anhydromuropeptides recycling I
-
-
Peptidoglycan biosynthesis
-
-
peptidoglycan biosynthesis
-
-
UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)
-
-
UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)
-
-
UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)
-
-
aerobic respiration I (cytochrome c)
-
-
aerobic respiration II (cytochrome c) (yeast)
-
-
aerobic respiration III (alternative oxidase pathway)
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-
Oxidative phosphorylation
-
-
propionate fermentation
-
-
succinate to cytochrome bd oxidase electron transfer
-
-
succinate to cytochrome bo oxidase electron transfer
-
-
glycerol-3-phosphate to fumarate electron transfer
-
-
hydrogen to fumarate electron transfer
-
-
NADH to fumarate electron transfer
-
-
3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)
-
-
heme b biosynthesis II (oxygen-independent)
-
-
Porphyrin and chlorophyll metabolism
-
-
4-aminobutanoate degradation V
-
-
Arginine biosynthesis
-
-
ethylene biosynthesis IV (engineered)
-
-
L-glutamate degradation I
-
-
L-glutamate degradation V (via hydroxyglutarate)
-
-
Taurine and hypotaurine metabolism
-
-
D-Arginine and D-ornithine metabolism
-
-
L-lysine degradation V
-
-
Penicillin and cephalosporin biosynthesis
-
-
Isoquinoline alkaloid biosynthesis
-
-
L-phenylalanine degradation IV (mammalian, via side chain)
-
-
L-tryptophan degradation VI (via tryptamine)
-
-
melatonin degradation II
-
-
Phenylalanine metabolism
-
-
tryptophan metabolism
-
-
L-lysine degradation II (L-pipecolate pathway)
-
-
L-lysine degradation VII
-
-
Tropane, piperidine and pyridine alkaloid biosynthesis
-
-
L-threonine degradation III (to methylglyoxal)
-
-
phenylethylamine degradation I
-
-
beta-alanine biosynthesis I
-
-
N-methyl-Delta1-pyrrolinium cation biosynthesis
-
-
glycine biosynthesis II
-
-
methylamine degradation I
-
-
folate transformations II (plants)
-
-
folate transformations III (E. coli)
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-
One carbon pool by folate
-
-
tetrahydrofolate biosynthesis
-
-
tetrahydrofolate metabolism
-
-
L-lysine degradation XI (mammalian)
-
-
pyruvate fermentation to opines
-
-
folate transformations I
-
-
Riboflavin metabolism
-
-
spermine and spermidine degradation I
-
-
beta-alanine biosynthesis IV
-
-
spermine and spermidine degradation III
-
-
(5R)-carbapenem carboxylate biosynthesis
L-citrulline biosynthesis
-
-
L-Ndelta-acetylornithine biosynthesis
-
-
proline to cytochrome bo oxidase electron transfer
-
-
superpathway of photosynthetic hydrogen production
-
-
Ubiquinone and other terpenoid-quinone biosynthesis
-
-
vitamin K-epoxide cycle
-
-
ascorbate recycling (cytosolic)
-
-
nitrate reduction II (assimilatory)
-
-
Aminobenzoate degradation
-
-
ammonia oxidation II (anaerobic)
-
-
nitrate reduction I (denitrification)
-
-
nitrate reduction VII (denitrification)
-
-
nitrifier denitrification
-
-
nitrite-dependent anaerobic methane oxidation
-
-
formate to nitrite electron transfer
-
-
nitrate reduction IV (dissimilatory)
-
-
2-oxoisovalerate decarboxylation to isobutanoyl-CoA
-
-
acetyl CoA biosynthesis
-
-
pyruvate decarboxylation to acetyl CoA
-
-
glutathione metabolism
-
-
glutathione-peroxide redox reactions
-
-
Selenocompound metabolism
-
-
gliotoxin biosynthesis
-
-
dissimilatory sulfate reduction I (to hydrogen sufide))
-
-
dissimilatory sulfate reduction II (to thiosulfate)
-
-
sulfite oxidation III
-
-
o-diquinones biosynthesis
-
-
methanol oxidation to formaldehyde IV
-
-
reactive oxygen species degradation
-
-
superoxide radicals degradation
-
-
baicalein degradation (hydrogen peroxide detoxification)
-
-
betanidin degradation
-
-
justicidin B biosynthesis
-
-
luteolin triglucuronide degradation
-
-
matairesinol biosynthesis
-
-
thyroid hormone biosynthesis
-
-
Arachidonic acid metabolism
-
-
arachidonic acid metabolism
-
-
hydrogen production III
-
-
hydrogen production VI
-
-
hydrogen production VIII
-
-
hydrogen oxidation I (aerobic)
-
-
divinyl ether biosynthesis II
-
-
jasmonic acid biosynthesis
-
-
Linoleic acid metabolism
-
-
anandamide lipoxygenation
-
-
15-epi-lipoxin biosynthesis
-
-
aspirin triggered resolvin D biosynthesis
-
-
aspirin triggered resolvin E biosynthesis
-
-
leukotriene biosynthesis
-
-
resolvin D biosynthesis
-
-
3-hydroxy-4-methyl-anthranilate biosynthesis I
-
-
3-hydroxy-4-methyl-anthranilate biosynthesis II
-
-
L-tryptophan degradation I (via anthranilate)
-
-
L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
-
-
L-tryptophan degradation XI (mammalian, via kynurenine)
-
-
procollagen hydroxylation and glycosylation
-
-
nitric oxide biosynthesis II (mammals)
-
-
1,5-anhydrofructose degradation
-
-
acetone degradation I (to methylglyoxal)
-
-
acetone degradation III (to propane-1,2-diol)
-
-
Amaryllidacea alkaloids biosynthesis
-
-
bupropion degradation
-
-
melatonin degradation I
-
-
nicotine degradation IV
-
-
nicotine degradation V
-
-
vanillin biosynthesis I
-
-
bacterial bioluminescence
-
-
(S)-reticuline biosynthesis I
-
-
(S)-reticuline biosynthesis II
-
-
betalamic acid biosynthesis
-
-
catecholamine biosynthesis
rosmarinic acid biosynthesis II
-
-
serotonin and melatonin biosynthesis
-
-
Biosynthesis of unsaturated fatty acids
-
-
oleate biosynthesis II (animals and fungi)
-
-
sorgoleone biosynthesis
-
-
C20 prostanoid biosynthesis
-
-
ethylene biosynthesis III (microbes)
-
-
adenosine nucleotides degradation II
-
-
caffeine degradation III (bacteria, via demethylation)
-
-
guanosine nucleotides degradation I
-
-
guanosine nucleotides degradation II
-
-
guanosine nucleotides degradation III
-
-
purine nucleobases degradation I (anaerobic)
-
-
theophylline degradation
-
-
formate oxidation to CO2
-
-
oxalate degradation III
-
-
oxalate degradation VI
-
-
reductive acetyl coenzyme A pathway
-
-
photosynthesis light reactions
-
-
nitrogen fixation I (ferredoxin)
-
-
3,5-dimethoxytoluene biosynthesis
-
-
Betalain biosynthesis
-
-
betaxanthin biosynthesis
-
-
guaiacol biosynthesis
-
-
L-methionine biosynthesis I
-
-
L-methionine biosynthesis III
-
-
L-methionine salvage from L-homocysteine
-
-
pyrimidine deoxyribonucleosides salvage
-
-
pyrimidine deoxyribonucleotides biosynthesis from CTP
-
-
pyrimidine deoxyribonucleotides de novo biosynthesis I
-
-
pyrimidine deoxyribonucleotides de novo biosynthesis II
-
-
pyrimidine deoxyribonucleotides de novo biosynthesis IV
-
-
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
-
-
ferulate and sinapate biosynthesis
-
-
free phenylpropanoid acid biosynthesis
-
-
phenylpropanoids methylation (ice plant)
-
-
suberin monomers biosynthesis
superpathway of scopolin and esculin biosynthesis
-
-
cyclopropane fatty acid (CFA) biosynthesis
-
-
sterculate biosynthesis
-
-
capsaicin biosynthesis
-
-
chlorogenic acid biosynthesis I
-
-
coumarins biosynthesis (engineered)
-
-
Flavonoid biosynthesis
-
-
scopoletin biosynthesis
-
-
Stilbenoid, diarylheptanoid and gingerol biosynthesis
-
-
pinitol biosynthesis I
-
-
pyrimidine deoxyribonucleotides de novo biosynthesis III
-
-
sakuranetin biosynthesis
-
-
Cyanoamino acid metabolism
-
-
glycine betaine degradation I
-
-
glycine betaine degradation II (mammalian)
-
-
glycine biosynthesis I
-
-
L-arginine biosynthesis I (via L-ornithine)
-
-
L-arginine biosynthesis II (acetyl cycle)
-
-
L-arginine biosynthesis IV (archaebacteria)
-
-
L-citrulline degradation
-
-
L-proline biosynthesis II (from arginine)
-
-
arachidonate biosynthesis I (6-desaturase, lower eukaryotes)
-
-
dimorphecolate biosynthesis
-
-
docosahexaenoate biosynthesis I (lower eukaryotes)
-
-
hydroxylated fatty acid biosynthesis (plants)
-
-
icosapentaenoate biosynthesis I (lower eukaryotes)
-
-
linoleate biosynthesis I (plants)
-
-
phosphatidylcholine acyl editing
-
-
phosphatidylcholine biosynthesis VII
-
-
phospholipid remodeling (phosphatidylcholine, yeast)
-
-
phospholipid remodeling (phosphatidylethanolamine, yeast)
-
-
ricinoleate biosynthesis
-
-
sterol:steryl ester interconversion (yeast)
-
-
bryostatin biosynthesis
-
-
fatty acid biosynthesis initiation (bacteria and plants)
-
-
fatty acid biosynthesis initiation (mitochondria)
-
-
fatty acid biosynthesis initiation (plant mitochondria)
-
-
mupirocin biosynthesis
-
-
superpathway of fatty acid biosynthesis initiation (E. coli)
-
-
pyruvate fermentation to acetate IV
-
-
aromatic polyketides biosynthesis
-
-
flavonoid biosynthesis
-
-
flavonoid biosynthesis (in equisetum)
-
-
flavonoid di-C-glucosylation
-
-
naringenin biosynthesis (engineered)
-
-
phloridzin biosynthesis
-
-
xanthohumol biosynthesis
-
-
fatty acid biosynthesis initiation (animals and fungi, cytoplasm)
-
-
palmitate biosynthesis (animals and fungi, cytoplasm)
-
-
lipid IVA biosynthesis (E. coli)
-
-
lipid IVA biosynthesis (P. putida)
-
-
Lipopolysaccharide biosynthesis
-
-
autoinducer AI-1 biosynthesis
-
-
(9Z)-tricosene biosynthesis
-
-
arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)
-
-
arachidonate biosynthesis V (8-detaturase, mammals)
-
-
Fatty acid elongation
-
-
icosapentaenoate biosynthesis III (8-desaturase, mammals)
-
-
icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)
-
-
juniperonate biosynthesis
-
-
sciadonate biosynthesis
-
-
stearate biosynthesis I (animals)
-
-
ultra-long-chain fatty acid biosynthesis
-
-
very long chain fatty acid biosynthesis I
-
-
very long chain fatty acid biosynthesis II
-
-
CMP-pseudaminate biosynthesis
-
-
(Kdo)2-lipid A biosynthesis I (E. coli)
-
-
superpathway of (Kdo)2-lipid A biosynthesis
-
-
NAD salvage pathway V (PNC V cycle)
-
-
D-Glutamine and D-glutamate metabolism
-
-
hypoglycin biosynthesis
-
-
protein ubiquitination
-
-
ethylene biosynthesis V (engineered)
-
-
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)
-
-
D-xylose degradation IV
-
-
glycolate and glyoxylate degradation II
-
-
L-arabinose degradation IV
-
-
ferrichrome A biosynthesis
-
-
Synthesis and degradation of ketone bodies
-
-
coenzyme B biosynthesis
-
-
FeMo cofactor biosynthesis
-
-
L-lysine biosynthesis IV
-
-
L-lysine biosynthesis V
-
-
Starch and sucrose metabolism
-
-
glycogen biosynthesis
-
-
glycogen biosynthesis II (from UDP-D-Glucose)
-
-
sucrose degradation II (sucrose synthase)
-
-
sucrose biosynthesis II
-
-
sucrose biosynthesis III
-
-
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide
-
-
biosynthesis of Lewis epitopes (H. pylori)
-
-
complex N-linked glycan biosynthesis (vertebrates)
-
-
Glycosaminoglycan biosynthesis - keratan sulfate
-
-
i antigen and I antigen biosynthesis
-
-
N-Glycan biosynthesis
-
-
terminal O-glycans residues modification (via type 2 precursor disaccharide)
-
-
Various types of N-glycan biosynthesis
-
-
lipid A-core biosynthesis (E. coli K-12)
-
-
ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide
-
-
complex N-linked glycan biosynthesis (plants)
-
-
Glycosphingolipid biosynthesis - lacto and neolacto series
-
-
Glycosphingolipid biosynthesis - globo and isoglobo series
-
-
lacto-series glycosphingolipids biosynthesis
-
-
Escherichia coli serotype O86 O-antigen biosynthesis
-
-
mucin core 1 and core 2 O-glycosylation
-
-
Mucin type O-glycan biosynthesis
-
-
O-antigen biosynthesis
-
-
Other types of O-glycan biosynthesis
-
-
peptidoglycan biosynthesis II (staphylococci)
-
-
peptidoglycan biosynthesis III (mycobacteria)
-
-
peptidoglycan biosynthesis IV (Enterococcus faecium)
-
-
peptidoglycan biosynthesis V (beta-lactam resistance)
-
-
peptidoglycan maturation (meso-diaminopimelate containing)
-
-
neolacto-series glycosphingolipids biosynthesis
-
-
Mannose type O-glycan biosynthesis
-
-
protein O-[N-acetyl]-glucosylation
-
-
adenine and adenosine salvage I
-
-
adenine and adenosine salvage III
-
-
adenine and adenosine salvage V
-
-
arsenate detoxification I (mammalian)
-
-
fluoroacetate and fluorothreonine biosynthesis
-
-
guanine and guanosine salvage
-
-
nucleoside and nucleotide degradation (archaea)
-
-
purine deoxyribonucleosides degradation I
-
-
purine deoxyribonucleosides degradation II
-
-
purine ribonucleosides degradation
-
-
salinosporamide A biosynthesis
-
-
xanthine and xanthosine salvage
-
-
pyrimidine deoxyribonucleosides degradation
-
-
guanine and guanosine salvage II
-
-
pyrimidine nucleobases salvage I
-
-
NAD biosynthesis III (from nicotinamide)
-
-
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
-
-
NAD de novo biosynthesis I (from aspartate)
-
-
nicotine biosynthesis
-
-
superpathway of nicotine biosynthesis
-
-
S-methyl-5'-thioadenosine degradation II
-
-
queuosine biosynthesis I (de novo)
-
-
queuosine biosynthesis III (queuosine salvage)
-
-
ganglio-series glycosphingolipids biosynthesis
-
-
Kdo transfer to lipid IVA I (E. coli)
-
-
Kdo transfer to lipid IVA II (Haemophilus)
-
-
Kdo transfer to lipid IVA IV (P. putida)
-
-
protein N-glycosylation initial phase (eukaryotic)
-
-
2'-deoxymugineic acid phytosiderophore biosynthesis
-
-
ethylene biosynthesis I (plants)
-
-
L-methionine degradation I (to L-homocysteine)
-
-
S-adenosyl-L-methionine biosynthesis
-
-
S-adenosyl-L-methionine cycle II
-
-
flavin biosynthesis I (bacteria and plants)
-
-
flavin biosynthesis II (archaea)
-
-
flavin biosynthesis III (fungi)
-
-
spermidine biosynthesis I
-
-
4-hydroxy-2-nonenal detoxification
-
-
camalexin biosynthesis
-
-
glutathione-mediated detoxification I
-
-
glutathione-mediated detoxification II
-
-
indole glucosinolate activation (intact plant cell)
-
-
pentachlorophenol degradation
-
-
di-trans,poly-cis-undecaprenyl phosphate biosynthesis
-
-
L-nicotianamine biosynthesis
-
-
L-cysteine biosynthesis I
-
-
seleno-amino acid biosynthesis (plants)
-
-
homocysteine and cysteine interconversion
-
-
L-cysteine biosynthesis VI (from L-methionine)
-
-
L-methionine biosynthesis II (plants)
-
-
3-dehydroquinate biosynthesis I
-
-
CMP-3-deoxy-D-manno-octulosonate biosynthesis
-
-
CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis
-
-
CMP-N-acetylneuraminate biosynthesis II (bacteria)
-
-
metabolism of amino sugars and derivatives
-
-
octaprenyl diphosphate biosynthesis
-
-
ubiquinone biosynthesis
-
-
1,4-dihydroxy-6-naphthoate biosynthesis
-
-
1,4-dihydroxy-6-naphthoate biosynthesis I
-
-
1,4-dihydroxy-6-naphthoate biosynthesis II
-
-
(R)-cysteate degradation
-
-
aspartate and asparagine metabolism
-
-
coenzyme M biosynthesis
-
-
coenzyme M biosynthesis II
-
-
L-asparagine degradation III (mammalian)
-
-
L-aspartate biosynthesis
-
-
L-aspartate degradation I
-
-
L-glutamate degradation II
-
-
L-phenylalanine biosynthesis I
-
-
L-phenylalanine degradation II (anaerobic)
-
-
L-phenylalanine degradation VI (Stickland reaction)
-
-
Novobiocin biosynthesis
-
-
sulfolactate degradation III
-
-
L-alanine biosynthesis II
-
-
L-alanine degradation III
-
-
L-arginine degradation VI (arginase 2 pathway)
-
-
L-ornithine biosynthesis II
-
-
L-ornithine degradation II (Stickland reaction)
-
-
L-proline biosynthesis III (from L-ornithine)
-
-
4-aminobutanoate degradation I
-
-
4-aminobutanoate degradation II
-
-
beta-alanine degradation I
-
-
L-glutamate degradation IV
-
-
nicotine degradation I (pyridine pathway)
-
-
CMP-diacetamido-8-epilegionaminic acid biosynthesis
-
-
UDP-N,N'-diacetylbacillosamine biosynthesis
-
-
Glucosinolate biosynthesis
-
-
L-alanine biosynthesis I
-
-
L-isoleucine biosynthesis II
-
-
L-isoleucine biosynthesis IV
-
-
L-isoleucine biosynthesis V
-
-
L-isoleucine degradation I
-
-
L-leucine biosynthesis
-
-
L-leucine degradation I
-
-
L-leucine degradation IV (Stickland reaction)
-
-
L-valine degradation I
-
-
L-serine biosynthesis II
-
-
biotin biosynthesis from 8-amino-7-oxononanoate I
-
-
2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactosyl-diphospho-ditrans,octacis-undecaprenol biosynthesis
-
-
UDP-yelosamine biosynthesis
-
-
GDP-glucose biosynthesis
-
-
glucose and glucose-1-phosphate degradation
-
-
glycogen degradation I
-
-
glycogen degradation II
-
-
Neomycin, kanamycin and gentamicin biosynthesis
-
-
Streptomycin biosynthesis
-
-
sucrose degradation III (sucrose invertase)
-
-
trehalose degradation I (low osmolarity)
-
-
trehalose degradation II (cytosolic)
-
-
trehalose degradation IV
-
-
trehalose degradation V
-
-
UDP-N-acetyl-D-galactosamine biosynthesis II
-
-
UDP-N-acetyl-D-glucosamine biosynthesis II
-
-
D-galactose degradation I (Leloir pathway)
-
-
D-galactose detoxification
-
-
degradation of hexoses
-
-
stachyose degradation
-
-
cell-surface glycoconjugate-linked phosphocholine biosynthesis
-
-
phosphatidylcholine biosynthesis I
-
-
phosphatidylethanolamine bioynthesis
-
-
plasmalogen biosynthesis
-
-
type IV lipoteichoic acid biosynthesis (S. pneumoniae)
-
-
coenzyme A metabolism
-
-
phosphopantothenate biosynthesis I
-
-
phosphopantothenate biosynthesis II
-
-
superpathway of coenzyme A biosynthesis III (mammals)
-
-
1-butanol autotrophic biosynthesis (engineered)
-
-
glycolysis V (Pyrococcus)
-
-
photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
-
-
purine deoxyribonucleosides salvage
-
-
phosphatidate metabolism, as a signaling molecule
-
-
type I lipoteichoic acid biosynthesis (S. aureus)
-
-
3-phosphoinositide biosynthesis
-
-
Inositol phosphate metabolism
-
-
acetate and ATP formation from acetyl-CoA I
-
-
gallate degradation III (anaerobic)
-
-
glycine degradation (Stickland reaction)
-
-
L-lysine fermentation to acetate and butanoate
-
-
L-threonine degradation I
-
-
methanogenesis from acetate
-
-
pyruvate fermentation to acetate II
-
-
creatine-phosphate biosynthesis
-
-
adenosine ribonucleotides de novo biosynthesis
-
-
adenosine deoxyribonucleotides de novo biosynthesis
-
-
adenosine deoxyribonucleotides de novo biosynthesis II
-
-
guanosine deoxyribonucleotides de novo biosynthesis I
-
-
guanosine deoxyribonucleotides de novo biosynthesis II
-
-
pyrimidine deoxyribonucleotide phosphorylation
-
-
UTP and CTP de novo biosynthesis
-
-
thiamine diphosphate biosynthesis I (E. coli)
-
-
thiamine diphosphate biosynthesis II (Bacillus)
-
-
coenzyme A biosynthesis I (prokaryotic)
-
-
coenzyme A biosynthesis II (eukaryotic)
-
-
UDP-alpha-D-glucose biosynthesis I
-
-
d-mannose degradation
-
-
GDP-mannose biosynthesis
-
-
L-ascorbate biosynthesis I (L-galactose pathway)
-
-
GDP-L-fucose biosynthesis II (from L-fucose)
-
-
phosphatidylserine and phosphatidylethanolamine biosynthesis I
-
-
superpathway of phospholipid biosynthesis II (plants)
-
-
cardiolipin biosynthesis
-
-
beta-D-galactosaminyl-(1rarr3)-N-acetyl-alpha-D-galactosamine biosynthesis
-
-
enterobacterial common antigen biosynthesis
-
-
Escherichia coli serotype O9a O-antigen biosynthesis
-
-
poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis
-
-
poly(glycerol phosphate) wall teichoic acid biosynthesis
-
-
poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)
-
-
poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)
-
-
teichoic acid biosynthesis
-
-
[2Fe-2S] iron-sulfur cluster biosynthesis
-
-
thyroid hormone metabolism II (via conjugation and/or degradation)
-
-
3-oxoadipate degradation
-
-
4-hydroxymandelate degradation
-
-
4-methylcatechol degradation (ortho cleavage)
-
-
Aminoacyl-tRNA biosynthesis
-
-
L-selenocysteine biosynthesis I (bacteria)
-
-
selenocysteine biosynthesis
-
-
L-selenocysteine biosynthesis II (archaea and eukaryotes)
-
-
methyl indole-3-acetate interconversion
-
-
methylsalicylate degradation
-
-
superpathway of methylsalicylate metabolism
-
-
Bisphenol degradation
-
-
triacylglycerol degradation
-
-
anandamide biosynthesis I
-
-
anandamide biosynthesis II
-
-
Ether lipid metabolism
-
-
phospholipid remodeling (phosphatidate, yeast)
-
-
plasmalogen degradation
-
-
degradation of sugar alcohols
-
-
sophorosyloxydocosanoate deacetylation
-
-
glucose degradation (oxidative)
-
-
L-ascorbate biosynthesis IV
-
-
L-ascorbate biosynthesis VI (engineered pathway)
-
-
sorbitol biosynthesis II
-
-
chlorogenic acid degradation
-
-
sporopollenin precursors biosynthesis
-
-
stearate biosynthesis III (fungi)
-
-
2-oxobutanoate degradation II
-
-
3-phenylpropionate degradation
-
-
firefly bioluminescence
-
-
diethylphosphate degradation
-
-
sulfopterin metabolism
-
-
phosphate acquisition
-
-
L-serine biosynthesis I
-
-
2-arachidonoylglycerol biosynthesis
-
-
diacylglycerol and triacylglycerol biosynthesis
-
-
palmitoyl ethanolamide biosynthesis
-
-
Sphingolipid metabolism
-
-
sphingosine metabolism
-
-
stigma estolide biosynthesis
-
-
NAD salvage pathway III (to nicotinamide riboside)
-
-
pyridine nucleotide cycling (plants)
-
-
tunicamycin biosynthesis
-
-
UTP and CTP dephosphorylation I
-
-
L-histidine biosynthesis
-
-
ADP-L-glycero-beta-D-manno-heptose biosynthesis
-
-
phosphatidylcholine resynthesis via glycerophosphocholine
-
-
choline biosynthesis III
-
-
glycine betaine biosynthesis
-
-
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
-
-
D-myo-inositol-5-phosphate metabolism
-
-
sphingolipid biosynthesis (mammals)
-
-
sphingomyelin metabolism
-
-
chlorpyrifos degradation
-
-
degradation of aromatic, nitrogen containing compounds
-
-
methyl parathion degradation
-
-
parathion degradation
-
-
chitin degradation I (archaea)
-
-
chitin degradation II (Vibrio)
-
-
chitin degradation III (Serratia)
-
-
Other glycan degradation
-
-
alpha-tomatine degradation
-
-
cellulose degradation II (fungi)
-
-
coumarin biosynthesis (via 2-coumarate)
-
-
ginsenoside metabolism
-
-
linamarin degradation
-
-
linustatin bioactivation
-
-
lotaustralin degradation
-
-
neolinustatin bioactivation
-
-
melibiose degradation
-
-
metabolism of disaccharids
-
-
Glycosaminoglycan degradation
-
-
Glycosphingolipid biosynthesis - ganglio series
-
-
lactose degradation II
-
-
xyloglucan degradation II (exoglucanase)
-
-
sucrose degradation V (sucrose alpha-glucosidase)
-
-
beta-D-glucuronide and D-glucuronate degradation
-
-
degradation of sugar acids
-
-
Flavone and flavonol biosynthesis
-
-
rutin degradation (plants)
-
-
anhydromuropeptides recycling II
-
-
lactose degradation III
-
-
protein N-glycosylation processing phase (plants and animals)
-
-
amygdalin and prunasin degradation
-
-
aromatic glucosinolate activation
-
-
glucosinolate activation
-
-
indole glucosinolate activation (herbivore attack)
-
-
autoinducer AI-2 biosynthesis I
-
-
autoinducer AI-2 biosynthesis II (Vibrio)
-
-
S-adenosyl-L-methionine cycle I
-
-
S-methyl-5'-thioadenosine degradation I
-
-
S-methyl-5'-thioadenosine degradation IV
-
-
muropeptide degradation
-
-
Arg/N-end rule pathway (eukaryotic)
-
-
glutamate removal from folates
-
-
felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis
-
-
glutathione degradation (DUG pathway - yeast)
-
-
nocardicin A biosynthesis
-
-
lipoprotein posttranslational modification
-
-
L-asparagine degradation I
-
-
superpathway of L-aspartate and L-asparagine biosynthesis
-
-
glutaminyl-tRNAgln biosynthesis via transamidation
-
-
L-asparagine biosynthesis III (tRNA-dependent)
-
-
L-glutamine degradation I
-
-
acrylonitrile degradation I
-
-
indole-3-acetate biosynthesis II
-
-
indole-3-acetate biosynthesis III (bacteria)
-
-
indole-3-acetate biosynthesis IV (bacteria)
-
-
L-arginine degradation X (arginine monooxygenase pathway)
-
-
ceramide degradation (generic)
-
-
cyanide detoxification II
-
-
uracil degradation I (reductive)
-
-
allantoin degradation
-
-
allantoin degradation to ureidoglycolate I (urea producing)
-
-
allantoin degradation to ureidoglycolate II (ammonia producing)
-
-
canavanine degradation
-
-
L-arginine degradation VII (arginase 3 pathway)
-
-
putrescine biosynthesis III
-
-
L-arginine degradation V (arginine deiminase pathway)
-
-
L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway)
-
-
putrescine biosynthesis II
-
-
pyrimidine ribonucleosides degradation
-
-
pyrimidine ribonucleosides salvage I
-
-
pyrimidine ribonucleosides salvage II
-
-
formaldehyde oxidation VII (THF pathway)
-
-
formate assimilation into 5,10-methylenetetrahydrofolate
-
-
L-histidine degradation III
-
-
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria)
-
-
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate
-
-
6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)
-
-
toxoflavin biosynthesis
-
-
indole-3-acetate biosynthesis V (bacteria and fungi)
-
-
base-degraded thiamine salvage
-
-
thiamine salvage IV (yeast)
-
-
(aminomethyl)phosphonate degradation
-
-
glyphosate degradation III
-
-
oxidative phosphorylation
-
-
acetaldehyde biosynthesis II
-
-
long chain fatty acid ester synthesis (engineered)
-
-
pyruvate fermentation to acetate VIII
-
-
pyruvate fermentation to acetoin III
-
-
4-hydroxymandelate degradation
-
-
indole-3-acetate degradation II
-
-
mandelate degradation I
-
-
beta-alanine biosynthesis III
-
-
L-glutamate degradation IX (via 4-aminobutanoate)
-
-
superpathway of ornithine degradation
-
-
arginine dependent acid resistance
-
-
L-arginine degradation III (arginine decarboxylase/agmatinase pathway)
-
-
putrescine biosynthesis I
-
-
spermidine biosynthesis III
-
-
histamine biosynthesis
-
-
CO2 fixation into oxaloacetate (anaplerotic)
-
-
Methanobacterium thermoautotrophicum biosynthetic metabolism
-
-
spermine biosynthesis
-
-
formaldehyde assimilation II (assimilatory RuMP Cycle)
-
-
3,6-anhydro-alpha-L-galactopyranose degradation
-
-
4-deoxy-L-threo-hex-4-enopyranuronate degradation
-
-
D-fructuronate degradation
-
-
D-galacturonate degradation I
-
-
D-glucosaminate degradation
-
-
Entner-Doudoroff shunt
-
-
3-hydroxypropanoate cycle
-
-
3-hydroxypropanoate/4-hydroxybutanate cycle
-
-
glyoxylate assimilation
-
-
quinate degradation I
-
-
quinate degradation II
-
-
hydrogen sulfide biosynthesis II (mammalian)
-
-
L-cysteine biosynthesis III (from L-homocysteine)
-
-
GDP-D-perosamine biosynthesis
-
-
GDP-L-colitose biosynthesis
-
-
GDP-L-fucose biosynthesis I (from GDP-D-mannose)
-
-
GDP-mycosamine biosynthesis
-
-
pseudouridine degradation
-
-
Fluorobenzoate degradation
-
-
superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis
-
-
UDP-N-acetyl-beta-L-fucosamine biosynthesis
-
-
UDP-N-acetyl-beta-L-quinovosamine biosynthesis
-
-
UDP-N-acetyl-alpha-D-fucosamine biosynthesis
-
-
UDP-N-acetyl-alpha-D-quinovosamine biosynthesis
-
-
hyaluronan degradation
-
-
heparan sulfate degradation
-
-
chondroitin sulfate degradation I (bacterial)
-
-
dermatan sulfate degradation I (bacterial)
-
-
L-threonine biosynthesis
-
-
Vitamin B6 metabolism
-
-
drosopterin and aurodrosopterin biosynthesis
-
-
erythro-tetrahydrobiopterin biosynthesis I
-
-
erythro-tetrahydrobiopterin biosynthesis II
-
-
threo-tetrahydrobiopterin biosynthesis
-
-
C5-Branched dibasic acid metabolism
-
-
L-glutamate degradation VI (to pyruvate)
-
-
canavanine biosynthesis
-
-
L-arginine biosynthesis III (via N-acetyl-L-citrulline)
-
-
5-oxo-L-proline metabolism
-
-
cyanide detoxification I
-
-
dimethyl sulfide biosynthesis from methionine
-
-
ansatrienin biosynthesis
-
-
L-alanine degradation I
-
-
pentose phosphate pathway (non-oxidative branch)
-
-
pentose phosphate pathway (partial)
-
-
colanic acid building blocks biosynthesis
-
-
mycolyl-arabinogalactan-peptidoglycan complex biosynthesis
-
-
superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis
-
-
UDP-alpha-D-galactose biosynthesis
-
-
teichuronic acid biosynthesis (B. subtilis 168)
-
-
UDP-N-acetyl-D-galactosamine biosynthesis I
-
-
bile acid biosynthesis, neutral pathway
cholesterol degradation to androstenedione II (cholesterol dehydrogenase)
-
-
degradation of pentoses
-
-
L-arabinose degradation I
-
-
L-rhamnose degradation I
-
-
GDP-D-glycero-alpha-D-manno-heptose biosynthesis
-
-
2,2'-dihydroxybiphenyl degradation
-
-
2,3-dihydroxybenzoate degradation
-
-
3-chlorocatechol degradation III (meta pathway)
-
-
4-amino-3-hydroxybenzoate degradation
-
-
4-chloronitrobenzene degradation
-
-
catechol degradation to 2-hydroxypentadienoate II
-
-
orthanilate degradation
-
-
protocatechuate degradation III (para-cleavage pathway)
-
-
eumelanin biosynthesis
-
-
beta-(1,4)-mannan degradation
-
-
beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation
-
-
CMP-legionaminate biosynthesis I
-
-
UDP-GlcNAc biosynthesis
-
-
UDP-N-acetyl-D-glucosamine biosynthesis I
-
-
2,3-dihydroxybenzoate biosynthesis
-
-
2-carboxy-1,4-naphthoquinol biosynthesis
-
-
Biosynthesis of siderophore group nonribosomal peptides
-
-
enterobactin biosynthesis
-
-
salicylate biosynthesis I
-
-
cholesterol biosynthesis
-
-
lanosterol biosynthesis
-
-
glycogen biosynthesis III (from alpha-maltose 1-phosphate)
-
-
trehalose biosynthesis IV
-
-
tetrapyrrole biosynthesis I (from glutamate)
-
-
itaconate degradation
-
-
4-coumarate degradation (aerobic)
-
-
4-coumarate degradation (anaerobic)
-
-
4-hydroxybenzoate biosynthesis III (plants)
-
-
6-gingerol analog biosynthesis (engineered)
-
-
caffeoylglucarate biosynthesis
-
-
phaselate biosynthesis
-
-
rosmarinic acid biosynthesis I
-
-
trans-caffeate degradation (aerobic)
-
-
umbelliferone biosynthesis
-
-
L-asparagine biosynthesis II
-
-
ammonia assimilation cycle I
-
-
ammonia assimilation cycle II
-
-
L-glutamine biosynthesis I
-
-
nitrate reduction V (assimilatory)
-
-
nitrate reduction VI (assimilatory)
-
-
pantothenate biosynthesis
-
-
ergothioneine biosynthesis I (bacteria)
-
-
glutathione biosynthesis
-
-
homoglutathione biosynthesis
-
-
ophthalmate biosynthesis
-
-
biotin biosynthesis from 8-amino-7-oxononanoate II
-
-
UTP and CTP dephosphorylation II
-
-
biotin-carboxyl carrier protein assembly
-
-
L-asparagine biosynthesis I
-
-
anapleurotic synthesis of oxalacetate
-
-
Aflatoxin biosynthesis
-
-
CO2 fixation in Crenarchaeota
-
-
jadomycin biosynthesis
-
-
acetone degradation II (to acetoacetate)
-
-
NAD/NADH phosphorylation and dephosphorylation
-
-
NADH to cytochrome bd oxidase electron transfer I
-
-
NADH to cytochrome bo oxidase electron transfer I
-
-
D-lactate to cytochrome bo oxidase electron transfer
-
-
glycerol-3-phosphate to cytochrome bo oxidase electron transfer
-
-
NADH to cytochrome bo oxidase electron transfer II
-
-
pyruvate to cytochrome bo oxidase electron transfer
-
-
ammonia oxidation IV (autotrophic ammonia oxidizers)
-
-
nitrate reduction X (dissimilatory, periplasmic)
-
-
arsenite oxidation I (respiratory)
-
-
oleandomycin activation/inactivation
-
-
octane oxidation
-
-
cis-vaccenate biosynthesis
-
-
cis-vaccenate biosynthesis
-
-
(5R)-carbapenem carboxylate biosynthesis
-
-
(5R)-carbapenem carboxylate biosynthesis
-
-
catecholamine biosynthesis
-
-
catecholamine biosynthesis
-
-
suberin monomers biosynthesis
-
-
suberin monomers biosynthesis
-
-
folate polyglutamylation
-
-
folate polyglutamylation
-
-
urea cycle
-
-
cyanate degradation
-
-
bile acid biosynthesis, neutral pathway
-
-
bile acid biosynthesis, neutral pathway
-
-
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