EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   2.3.1.26 | pregnenolone + oleoyl-CoA |
without cholesterol, pregnenolone is a poor ACAT substrate, with cholesterol, the Vmax for PREG esterification increases by 100fold |
Homo sapiens |
20-oxopregn-5-en-3beta-yl (9Z)-octadec-9-enoate + CoA |
- |
? |
| 2.3.1.26 | pregnenolone + oleoyl-CoA |
without cholesterol, pregnenolone is a poor ACAT substrate, with cholesterol, the Vmax for pregnenolone esterification increases by 100fold |
Homo sapiens |
20-oxopregn-5-en-3beta-yl (9Z)-octadec-9-enoate + CoA |
- |
? |
| 2.3.1.26 | more |
- |
Homo sapiens |
? |
- |
? |
| 2.3.1.26 | more |
- |
Saccharomyces cerevisiae |
? |
- |
? |
| 2.3.1.26 | more |
oleic acid is not incorporated into cholesterol esters by placental microsomes even in the presence of ATP, CoA and MgCl2 |
Homo sapiens |
? |
- |
? |
| 2.3.1.26 | more |
structural requirements of sterol substrate |
Rattus norvegicus |
? |
- |
? |
| 2.3.1.26 | more |
enzyme activity is regulated by the acyl-CoA binding protein ACBP |
Homo sapiens |
? |
- |
? |
| 2.3.1.26 | more |
the enzyme has a broad substrate specificity for sterols and acyl-CoAs |
Saccharomyces cerevisiae |
? |
- |
? |
| 2.3.1.26 | more |
campesterol is a poor substrate, indicating the alkyl side chain plays an important role in the enzyme reaction |
Rattus norvegicus |
? |
- |
? |
| 2.3.1.26 | more |
maximal ester formation is obtained when the longest chain on C-20 has five carbons and either an increase or decrease in the number of carbons reduce the amount of ester formed |
Rattus norvegicus |
? |
- |
? |
