EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.B84 | more |
IpeOMT1 does not catalyze the 7'-O-methylation of 7'-O-demethylcephaeline. IpeOMT1 shows broad substrate specificity towards the intermediates in emetine biosynthesis. IpeOMT1 dominantly catalyzes 6-O-methylation of the 6,7-dihydroxy- and 6-hydroxy-7-methoxyisoquinolines. The regional substrate specificity at the last step of emetine biosynthesis is restricted to 6'-O-methylation |
Carapichea ipecacuanha |
? |
- |
? |
2.1.1.B84 | more |
the enzyme is also active on 7'-O-demethylcephaeline forming cephaeline, overview |
Carapichea ipecacuanha |
? |
- |
? |
2.1.1.B84 | more |
substrate specificity of CiOMT2, overview |
Carapichea ipecacuanha |
? |
- |
? |
2.1.1.B84 | S-adenosyl-L-methionine + 7-O-methyl-N-deacetylisoipecoside |
- |
Carapichea ipecacuanha |
S-adenosyl-L-homocysteine + 6,7-O,O-dimethyl-N-deacetylisoipecoside |
- |
? |
2.1.1.B84 | S-adenosyl-L-methionine + N-deacetylisoipecoside |
- |
Carapichea ipecacuanha |
S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylipecoside |
- |
? |
2.1.1.B84 | S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside |
- |
Carapichea ipecacuanha |
S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside |
- |
? |
2.1.1.B84 | S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside |
the iminium cation, one of the spontaneous reaction products of 6-O-methyl-N-deacetylisoipecoside aglycon, might be an intermediate of emetine biosynthesis |
Carapichea ipecacuanha |
S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside |
- |
? |
2.1.1.B84 | S-adenosyl-L-methionine + (R)-norprotosinomenine |
- |
Carapichea ipecacuanha |
S-adenosyl-L-homocysteine + ? |
- |
? |
2.1.1.B84 | S-adenosyl-L-methionine + (R,S)-isococlaurine |
- |
Carapichea ipecacuanha |
S-adenosyl-L-homocysteine + ? |
- |
? |
2.1.1.B84 | S-adenosyl-L-methionine + (R,S)-isoorientaline |
- |
Carapichea ipecacuanha |
S-adenosyl-L-homocysteine + ? |
- |
? |